Digestion

Original Paper

Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes

Nwosu B.U.a · Maranda L.b

Author affiliations

Departments of aPediatrics, and bQuantitative Health Sciences, University of Massachusetts Medical School, Worcester, Mass., USA

Keywords: AdiposityInflammatory bowel diseaseCrohnߣs disease�A0;Ulcerative colitisChildren and adolescentsCeliac diseaseLactose intolerance

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Digestion 2015;92:1-7
https://doi.org/10.1159/000381895

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 05, 2015
Accepted: March 25, 2015
Published online: May 30, 2015
Issue release date: August 2015

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Background: The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. Aim: To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. Methods: Prepubertal children of ages 3-12 with either lactose intolerance (LI) (n = 38, age 8.61 ± 3.08, male/female 19/19), or celiac disease (CD) (n = 24) were compared to healthy controls (n = 49, age 7.95 ± 2.64, male/female 28/21). A separate cohort of combined prepubertal and pubertal subjects with inflammatory bowel disease (IBD) (n = 59, age 16.4 ± 2.2, male/female 31/27) were also compared to healthy controls (n = 116, male/female 49/67, age 14.6 ± 4.4). Vitamin D deficiency was defined as 25(OH)D of <50 nmol/l, overweight as body mass index (BMI) of ≥85th but <95th percentile, and obesity as BMI ≥95th percentile. Results: Among the controls, 25(OH)D was significantly higher in the normal-weight prepubertal controls vs. the overweight/obese controls (p = 0.001), and similarly so for the combined cohort of prepubertal and pubertal controls (p = 0.031). In contrast, there was no significant difference in 25(OH)D concentration between the normal-weight vs. overweight/obese patients with LI (p = 0.335), CD (p = 0.387), and IBD (p = 0.883). Conclusion: There is no association between adiposity and serum 25(OH)D in pediatric malabsorption syndromes.

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 05, 2015
Accepted: March 25, 2015
Published online: May 30, 2015
Issue release date: August 2015

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

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2015, Vol.92, No. 1

August 2015

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