Acta Haematologica
Case Report
Accelerated Phase of Chronic Myeloid Leukemia Presenting with Hypercalcemia and a Mediastinal MassQuitt M.a · Kelner J.b · Sova J.b · Froom P.a · Aghai E.aa Institute of Hematology and b Institute of Pathology, Lady Davis Carmel Hospital, Haifa, Israel
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Acta Haematol 1998;99:231–233
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Article / Publication Details
First-Page Preview
Published online: May 22, 1998
Issue release date: May 1998
Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Abstract
A patient with chronic myeloid leukemia developed hypercalcemia as a presenting sign of the accelerated phase of the disease. Ultrasound of the neck showed a large hypodense mass connected to the thyroid gland, which was thought to be a parathyorid tumor and the cause of the hypercalcemia. Histology of the surgically removed mass revealed a chloroma. The patient’s course was complicated by respiratory failure and metastatic calcinosis of the lung, an unusual finding in hypercalcemia of short duration.
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References
-
Oddel WD: Endocrine manifestations of tumors: Ectopic hormone production; in Wyngaarden JB, Smith LH (eds): Cecil Textbook of Medicine. Philadelphia, Saunders, 1985, pp 1077–1080.
- Breslau NA, McGuire JL, Zerwekh JE, Frenkel EP, Pak CYC: Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med 1984;100:1–7.
- Walter RM, Greenberg BR: Hypercalcemia in the accelerated phase of chronic myeloid leukemia. Cancer 1980;46:1174–1178.
- Attar E, Prokocimer M, Januszewicz E, Theodor E: Hypercalcemia complicating myelomonoblastic transformation of chronic myeloid leukemia. Acta Haematol 1988;79:211–212.
-
Tricto G, Boogaerts MA, Broeckaert-van Orshoven A, Criel A, Van Hoof A, Van den Berghe H: Hypercalcemia and diffuse osteolytic lesions in the acute phase of chronic myelogenous leukemia. Cancer 1983;52:831–845.
- Kornberg A, Amir G, Leizerowitz R, Rachmilewitz A: Hypercalcemia complicating a megakaryoblastic crisis of chronic myelocytic leukemia. Isr J Med Sci 1988;24:247–249.
-
Colby VT, Carrington LB: Infiltrative lung disease; in Thurlbeck MW (ed): Pathology of Lung. New York, Thieme, 1988, pp 496–498.
-
Dail OH: Metabolic and other diseases; in Dail OH, Hammar SP (eds): Pulmonary Pathology. New York, Springer, 1988, pp 548–551.
- Furukawa Y, Tanaka K, Hasuike T, Hirai M, Misu K, et al: Adult T-cell leukemia lymphoma with metastatic calcification. Rinsho Byori 1991;39:886–890.
- Mundi GR, Ibbotson KJ, D’Souza SM, Simpson EL, Jacobs JW, Martin TJ: The hypercalcemia of cancer. Clinical implications and pathogenic mechanisms. N Engl J Med 1984;310:1718–1727.
- Wysolmerski JJ, Aroadus AE: Hypercalcemia of malignancy: The central role of parathyroid hormone-related protein. Annu Rev Med 1994;45:189–200.
-
Seymour JF, Gagel RF: Calcitriol: The major humoral mediator of hypercalcemia in Hodgkin’s disease and non-Hodgkins disease lymphomas. Blood 1993;82:1384–1394.
- Firkin F, Seymour JF, Watson AM, Grill V, Martin TJ: Parathyroid hormone-related protein in hypercalcemia associated with haematological malignancy. Br J Haematol 1996;94:486–492.
- Sasaki Y, Takahashi T, Tsuyuoka R, Tanaka K, Ishida H, Nakao K, et al: Hypercalcemia mediated by parathyroid hormone-related protein in chronic myeloid leukemia (letter). Am J Hematol 1994;47:251–252.
- Seymour JF, Grill V, Martin TJ, Lee N, Firkin F: Hypercalcemia in the blastic phase of chronic myeloid leukemia associated with elevated parathyroid hormone related protein (letter). Leukemia 1993;7:1672–1675.
-
Ballard HS, Marcus AJ: Hypercalcemia in chronic myelogenous leukemia. N Engl J Med 1970;282:662–665.
-
Joyner MV, Dujardin P, Cassout JP, Andoly P: Hypercalcemia as complication of accelerated chronic granulocytic leukemia. Br Med J 1977;ii:1060.
Article / Publication Details
First-Page Preview
Published online: May 22, 1998
Issue release date: May 1998
Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
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