Nephron
Clinical Practice: Original Paper
One Year's Observational Study of Acute Kidney Injury Incidence in Primary Care; Frequency of Follow-Up Serum Creatinine and Mortality RiskBarton A.L.a · Mallard A.S.a · Parry R.G.bDepartments of aClinical Chemistry, and bNephrology, Royal Cornwall Hospital, Truro, UK
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Article / Publication Details
Received: December 12, 2014
Accepted: April 21, 2015
Published online: June 19, 2015
Issue release date: July 2015
Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Background/Aims: Publications on acute kidney injury (AKI) have concentrated on the inpatient population. We wanted to determine the extent of AKI in the community, its follow-up and patient impact. Method: Primary Care creatinine results for May 2012-April 2013 from Cornwall, United Kingdom, were screened for AKI. Results: Over 12 months, 991 AKI episodes were identified (0.4% of all Primary Care creatinine requests); 51% were AKI1, 29% AKI2 and 10% AKI3. Of these, 51% AKI1s, 72% AKI2s and 77% AKI3s had a repeat creatinine requested within 14 days as per National Institute for Health and Care Excellence (NICE) guidelines. Admissions (May 2012-July 2013) were identified on 46% AKI1s, 58% AKI2s and 65% AKI3s (p < 0.05). The median time from AKI identification to hospital admission was 33 days for AKI1, 12 days for AKI2 and 1 day for AKI3 (p < 0.05); with a median length of stay of 2, 4 and 7 days, respectively (p < 0.05). The 90-day mortality from AKI identification for the admitted patients was 12% AKI1s, 20% AKI2s and 27% AKI3s (p < 0.05) vs. 11, 21 and 65% (p < 0.05) for those that were not admitted. There was no significant difference in mortality for admitted patients vs. non-admitted patients, except for the AKI3s. Conclusion: AKI is associated with increased admission and mortality rates; although a large proportion of patients had repeat creatinine testing within 14 days, there was still a significant number with delayed follow-up. Education within Primary Care is required on how to prevent, identify, follow-up and manage AKI.
© 2015 S. Karger AG, Basel
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References
- Wallace K, Mallard AS, Stratton JD, Johnston PA, Dickinson S, Parry RG: Use of an electronic alert to identify patients with acute kidney injury. Clin Med 2014;14:22-26.
- NICE: Acute Kidney Injury: Prevention, Detection and Management of Acute Kidney Injury up to the Joint of Renal Replacement Therapy. London, NICE, 2013. http://guidance.nice.org.uk/CG169 (published August 28, 2013).
- Selby NM, Crowley L, Fluck RJ, McIntyre CW, Monaghan J, Lawson N, Kolhe NV: Use of electronic results reporting to diagnose and monitor AKI in hospitalized patients. Clin J Am Soc Nephrol 2012;7:533-540.
- de Almeida DC, Donizetti-Oliveira C, Barbosa-Costa P, Origassa CS, Câmara NO: In search of mechanisms associated with mesenchymal stem cell-based therapies for acute kidney injury. Clin Biochem Rev 2013;34:131-144.
- Blakeman T, Harding S, O'Donoghue D: Acute kidney injury in the community: why primary care has an important role. Br J Gen Pract 2013;63:173-174.
-
Hawley C: Medication review 4: need a break? Advising patients on drug holidays. Br J Primary Care Nursing 2012;9:159-161.
- Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A; Acute Kidney Injury Network: Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007;11:R31.
-
Stewart J, Findlay G, Smith N, Kelly K, Mason M: Adding Insult to Injury: A Review of the Care of Patients Who Died in Hospital with a Primary Diagnosis of Acute Kidney Injury (Acute Renal Failure). A report by the National Confidential Enquiry into Patient Outcome and Death, 2009. http://www.ncepod.org.uk/2009aki.htm (accessed July, 2014).
-
NICE: Chronic Kidney Disease: Early Identification and Management of Chronic Kidney Disease in Adults in Primary and Secondary Care. London, UK, NICE, 2014, clinical guideline no. 182.
-
NHS England: Acute Kidney Injury (AKI) Algorithm. www.england.nhs.uk/ourwork/patientsafety/akiprogramme/aki-algorithm (accessed October, 2014).
-
Price C, Adams M, Mallard A, Dickinson S, Johnston P, Stratton J, Parry RG: Inpatient Acute Kidney Injury (AKI): Hospital (hAKI) versus Community Acquired (cAKI). British Renal Society Conference, 2013. http://www.britishrenal.org/Abstracts/Abstracts-2013.aspx (accessed July, 2014).
-
Barton AL, Mallard AS, Patterson A, Fleming SC: Identification of acute kidney injury in primary care. Ann Clin Biochem 2013;50:75.
-
NHS Kernow Clinical Commissioning Group, Localities Page. http://www.kernowccg.nhs.uk/localities (accessed March, 2015).
-
Office for National Statistics: 2011 Census Data Catalogue. http://www.ons.gov.uk/ons/guide-method/census/2011/census-data/2011-census-data-catalogue/index.html (accessed March, 2015).
-
Hazara A, Bhandari S: Community-acquired acute kidney injury: hospital admissions and outcomes. J Am Soc Nephrol 2013;24:2A.
- Zeng X, McMahon GM, Brunelli SM, Bates DW, Waikar SS: Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol 2014;9:12-20.
- Hobbs H, Bassett P, Wheeler T, Bedford M, Irving J, Stevens PE, Farmer CK: Do acute elevations of serum creatinine in primary care engender an increased mortality risk? BMC Nephrol 2014;15:206.
-
NHS Trust: Dr. Graham White, Senior Biomedical Scientist, Biochemistry Department, Royal Hampshire County Hospital, Hampshire Hospitals.
-
Garner AE, Harding SL, Bosomworth MP, Lewington AJP: A potential role for e-alerts in the management of community-acquired AKI in primary care. J R Coll Physicians Edinb 2012;42(suppl 19):36-50.
Article / Publication Details
Received: December 12, 2014
Accepted: April 21, 2015
Published online: June 19, 2015
Issue release date: July 2015
Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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