Case and Review
The Phytotherapeutic Fenugreek as Trigger of Toxic Epidermal NecrolysisBentele-Jaberg N.a · Guenova E.a · Mehra T.b · Nägeli M.a · Chang Y.-T.a · Cozzio A.a · French L.E.a · Hoetzenecker W.a
aDepartment of Dermatology and bMedical Directorate, University Hospital of Zurich, Zurich, Switzerland
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Article / Publication Details
We describe the case of a 32-year-old woman who presented to the hospital with generalized painful exanthema, blisters and erosions 1 month after giving birth to a healthy girl. The patient's medical history was inconspicuous for comorbidities; however, it included the incidental intake of pain killers and a herbal preparation (fenugreek), which she took regularly over the last 4 weeks to improve lactation. Based on the clinical characteristics, we suspected toxic epidermal necrolysis (TEN), a severe cutaneous adverse drug reaction, which was confirmed by skin biopsy. The patient was treated with high-dose intravenous human immunoglobulins and was discharged 2 weeks after hospital admission in good condition. The allergological workup identified fenugreek as the most likely causative agent. Given the increased self-medication of freely available phytotherapeutics by patients in industrialized countries, herbal mixtures should be taken into consideration in the diagnostic workup of TEN.
© 2015 S. Karger AG, Basel
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