Stereotactic and Functional Neurosurgery

Clinical Study

No Effect of Different Stimulation Conditions on Verbal Fluency and Visuospatial Orientation in Patients with Subthalamic Nucleus Deep Brain Stimulation

Yilmaz R.a · Akbostancı M.C.a · Mercan F.N.a · Sorgun M.H.a · Savaş A.b

Author affiliations

Departments of aNeurology and bNeurosurgery, Ankara University School of Medicine, Ankara, Turkey

Keywords: Deep brain stimulationSubthalamic nucleusVerbal fluencyVisuospatial orientationParkinsonߣs disease

Related Articles for ""
Stereotact Funct Neurosurg 2015;93:326-332
https://doi.org/10.1159/000438996

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: December 24, 2014
Accepted: July 27, 2015
Published online: September 10, 2015
Issue release date: October 2015

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Background: Subthalamic nucleus deep brain stimulation is an effective treatment for the symptomatic treatment of Parkinson's disease. Apart from the obvious motor benefits, some cognitive side effects have been reported, particularly in verbal fluency. Objectives: Our aim was to evaluate the effects of the stimulation on verbal fluency and visuospatial orientation with changing stimulation conditions in 35 patients with Parkinson's disease. Methods: Patients were randomized for their stimulation conditions as ‘both on', ‘both off', ‘right on', and ‘left on' and underwent verbal fluency and visuospatial orientation tasks during their drug-on periods. Letter and categorical fluency tasks and Benton's Judgment of Line Orientation Test were used for assessment. Results: Overall, 6 patients were excluded due to dementia or depression. For verbal fluency, the number of words they produced in 1 min was similar in four stimulation conditions (p > 0.05). No significant difference was found between stimulation conditions in the spatial orientation task. Conclusions: We were unable to find any significant changes in verbal fluency and visuospatial orientation task scores with different stimulation conditions. This result suggests that either stimulation has no effect on given domains or the effect is so small that more detailed batteries are required to detect the difference.

© 2015 S. Karger AG, Basel



Related Articles:

References

  1. Schupbach WM, Chastan N, Welter ML, Houeto JL, Mesnage V, Bonnet AM, Czernecki V, Maltete D, Hartmann A, Mallet L, Pidoux B, Dormont D, Navarro S, Cornu P, Mallet A, Agid Y: Stimulation of the subthalamic nucleus in Parkinson's disease: a 5-year follow-up. J Neurol Neurosurg Psychiatry 2005;76:1640-1644.
  2. Contarino MF, Daniele A, Sibilia AH, Romito LM, Bentivoglio AR, Gainotti G, Albanese A: Cognitive outcome 5 years after bilateral chronic stimulation of subthalamic nucleus in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:248-252.
  3. Halpern CH, Rick JH, Danish SF, Grossman M, Baltuch GH: Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease. Int J Geriatr Psychiatry 2009;24:443-451.
  4. Morrison CE, Borod JC, Brin MF, Raskin SA, Germano IM, Weisz DJ, Olanow CW: A program for neuropsychological investigation of deep brain stimulation (PNIDBS) in movement disorder patients: development, feasibility, and preliminary data. Neuropsychiatry Neuropsychol Behav Neurol 2000;13:204-219.
  5. Pillon B, Ardouin C, Damier P, Krack P, Houeto JL, Klinger H, Bonnet AM, Pollak P, Benabid AL, Agid Y: Neuropsychological changes between ‘off' and ‘on' STN or GPi stimulation in Parkinson's disease. Neurology 2000;55:411-418.
  6. Okun MS, Gallo BV, Mandybur G, Jagid J, Foote KD, Revilla FJ, Alterman R, Jankovic J, Simpson R, Junn F, Verhagen L, Arle JE, Ford B, Goodman RR, Stewart RM, Horn S, Baltuch GH, Kopell BH, Marshall F, Peichel D, Pahwa R, Lyons KE, Troster AI, Vitek JL, Tagliati M: Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol 2012;11:140-149.
  7. Daniele A, Albanese A, Contarino MF, Zinzi P, Barbier A, Gasparini F, Romito LM, Bentivoglio AR, Scerrati M: Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2003;74:175-182.
  8. Funkiewiez A, Ardouin C, Caputo E, Krack P, Fraix V, Klinger H, Chabardes S, Foote K, Benabid AL, Pollak P: Long-term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease. J Neurol Neurosurg Psychiatry 2004;75:834-839.
  9. Smeding HM, Speelman JD, Koning-Haanstra M, Schuurman PR, Nijssen P, van Laar T, Schmand B: Neuropsychological effects of bilateral STN stimulation in Parkinson disease: a controlled study. Neurology 2006;66:1830-1836.
  10. Schroeder U, Kuehler A, Lange KW, Haslinger B, Tronnier VM, Krause M, Pfister R, Boecker H, Ceballos-Baumann AO: Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Ann Neurol 2003;54:445-450.
  11. Wojtecki L, Timmermann L, Jorgens S, Sudmeyer M, Maarouf M, Treuer H, Gross J, Lehrke R, Koulousakis A, Voges J, Sturm V, Schnitzler A: Frequency-dependent reciprocal modulation of verbal fluency and motor functions in subthalamic deep brain stimulation. Arch Neurol 2006;63:1273-1276.
  12. Jahanshahi M, Ardouin CM, Brown RG, Rothwell JC, Obeso J, Albanese A, Rodriguez-Oroz MC, Moro E, Benabid AL, Pollak P, Limousin-Dowsey P: The impact of deep brain stimulation on executive function in Parkinson's disease. Brain 2000;123:1142-1154.
  13. Morrison CE, Borod JC, Perrine K, Beric A, Brin MF, Rezai A, Kelly P, Sterio D, Germano I, Weisz D, Olanow CW: Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson's disease. Arch Clin Neuropsychol 2004;19:165-181.
  14. Lacritz LH, Cullum CM, Frol AB, Dewey RB Jr, Giller CA: Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease. Brain Cogn 2000;42:364-378.
  15. Troster AI, Woods SP, Fields JA, Hanisch C, Beatty WW: Declines in switching underlie verbal fluency changes after unilateral pallidal surgery in Parkinson's disease. Brain Cogn 2002;50:207-217.
  16. Schuurman PR, Bruins J, Merkus MP, Bosch DA, Speelman JD: A comparison of neuropsychological effects of thalamotomy and thalamic stimulation. Neurology 2002;59:1232-1239.
  17. Damasio AR, Damasio H, Chui HC: Neglect following damage to frontal lobe or basal ganglia. Neuropsychologia 1980;18:123-132.
  18. Karnath HO, Himmelbach M, Rorden C: The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 2002;125:350-360.
  19. Parsons TD, Rogers SA, Braaten AJ, Woods SP, Troster AI: Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis. Lancet Neurol 2006;5:578-588.
  20. Alegret M, Junque C, Valldeoriola F, Vendrell P, Pilleri M, Rumia J, Tolosa E: Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. Arch Neurol 2001;58:1223-1227.
  21. Witt K, Kopper F, Deuschl G, Krack P: Subthalamic nucleus influences spatial orientation in extra-personal space. Mov Disord 2006;21:354-361.
  22. Nalcaci E, Kalaycioglu C, Gunes E, Cicek M: Reliability and validity of a handedness questionnaire (in Turkish). Turk Psikiyatri Derg 2002;13:99-106.
  23. Aydemir Ö: Validity and reliability of the Turkish version of the Hospital Anxiety and Depression Scale. Turk Psikiyatri Derg 1997;8:280-287.
  24. Gungen C, Ertan T, Eker E, Yasar R, Engin F: Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in a Turkish population (in Turkish). Turk Psikiyatri Derg 2002;13:273-281.
  25. Savas A, Akbostanci C, Yagmurlu B, Elibol B, Erden I, Kanpolat Y: A new method for subthalamic nucleus targeting using CT/MRI image-fusion technology. Acta Neurochir 2002;144:1076-1077.
  26. Savas A, Bozkurt M, Akbostanci C: A comparison between stereotactic targetting methods of the subthalamic nucleus in cases with Parkinson's disease. Acta Neurochir Suppl 2013;117:35-41.
  27. Tranel D, Vianna E, Manzel K, Damasio H, Grabowski T: Neuroanatomical correlates of the Benton Facial Recognition Test and Judgment of Line Orientation Test. J Clin Exp Neuropsychol 2009;31:219-233.
  28. Granziera C, Pollo C, Russmann H, Staedler C, Ghika J, Villemure JG, Burkhard PR, Vingerhoets FJ: Sub-acute delayed failure of subthalamic DBS in Parkinson's disease: the role of micro-lesion effect. Parkinsonism Relat Disord 2008;14:109-113.
  29. Pourfar M, Tang C, Lin T, Dhawan V, Kaplitt MG, Eidelberg D: Assessing the microlesion effect of subthalamic deep brain stimulation surgery with FDG PET. J Neurosurg 2009;110:1278-1282.
  30. Witt K, Pulkowski U, Herzog J, Lorenz D, Hamel W, Deuschl G, Krack P: Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease. Arch Neurol 2004;61:697-700.
  31. Witt K, Granert O, Daniels C, Volkmann J, Falk D, van Eimeren T, Deuschl G: Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial. Brain 2013;136:2109-2119.
  32. Bickel S, Alvarez L, Macias R, Pavon N, Leon M, Fernandez C, Houghton DJ, Salazar S, Rodriguez-Oroz MC, Juncos J, Guridi J, Delong M, Obeso JA, Litvan I: Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease. Parkinsonism Relat Disord 2010;16:535-539.
  33. Mikos A, Bowers D, Noecker AM, McIntyre CC, Won M, Chaturvedi A, Foote KD, Okun MS: Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency. Neuroimage 2011;54:S238-S246.
  34. Sjoberg RL, Lidman E, Haggstrom B, Hariz MI, Linder J, Fredricks A, Blomstedt P: Verbal fluency in patients receiving bilateral versus left-sided deep brain stimulation of the subthalamic nucleus for Parkinson's disease. J Int Neuropsychol Soc 2012;18:606-611.
  35. Healton EB, Navarro C, Bressman S, Brust JC: Subcortical neglect. Neurology 1982;32:776-778.
  36. Rafal RD, Posner MI: Deficits in human visual spatial attention following thalamic lesions. Proc Natl Acad Sci U S A 1987;84:7349-7353.
  37. Henderson JM, Annett LE, Ryan LJ, Chiang W, Hidaka S, Torres EM, Dunnett SB: Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat. Eur J Neurosci 1999;11:2749-2757.
  38. Temel Y, Blokland A, Steinbusch HWM, Visser-Vandewalle V: The functional role of the subthalamic nucleus in cognitive and limbic circuits. Prog Neurobiol 2005;76:393-413.
  39. Cooper SE, McIntyre CC, Fernandez HH, Vitek JL: Association of deep brain stimulation washout effects with Parkinson disease duration. JAMA Neurol 2013;70:95-99.
  40. Alberts JL, Voelcker-Rehage C, Hallahan K, Vitek M, Bamzai R, Vitek JL: Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients. Brain 2008;131:3348-3360.

Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: December 24, 2014
Accepted: July 27, 2015
Published online: September 10, 2015
Issue release date: October 2015

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2015, Vol.93, No. 5

October 2015

Article

Recommend This
TOP