European Neurology
Original Paper
Detection of Cortical Microbleeds in Postmortem Brains of Patients with Lewy Body Dementia: A 7.0-Tesla Magnetic Resonance Imaging Study with Neuropathological CorrelatesDe Reuck J.L. · Auger F. · Durieux N. · Cordonnier C. · Deramecourt V. · Lebert F. · Leys D. · Pasquier F. · Maurage C.-A. · Bordet R.INSERM U1171, Université de Lille 2, Lille, France
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Article / Publication Details
Received: August 21, 2015
Accepted: September 13, 2015
Published online: October 09, 2015
Issue release date: December 2015
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
Background: It is unclear whether associated cerebrovascular pathology contributes to the clinical spectrum of Lewy body dementia (LBD). Summary: The present postmortem 7.0-tesla MRI study investigates the anatomical distribution of cortical microbleeds (CoMBs) in LBD brains with and without associated Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). CoMBs predominated in the frontal section of the LBD brains and were associated to severe white matter lesions. No differences were observed when LBD brains with and without AD and CAA were compared. Key Messages: In LBD, there is a specific distribution of CoMBs that is different from that in other neurodegenerative diseases. The increase of frontal CoMBs is not due to the frequently associated AD and CAA features but due to the LBD itself.
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Article / Publication Details
Received: August 21, 2015
Accepted: September 13, 2015
Published online: October 09, 2015
Issue release date: December 2015
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
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