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Clinical Practice: Original Paper

Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population

Eriksen B.O.a,d,g · Løchen M.-L.b · Arntzen K.A.c, e · Bertelsen G.c, f · Winther Eilertsen B.-A.g · von Hanno T.c, i · Herder M.b, h · Jenssen T.G.a, j · Mathisen U.D.d · Melsom T.d · Njølstad I.b · Solbu M.D.d · Mathiesen E.B.c, e

Author affiliations

aMetabolic and Renal Research Group, Departments of bCommunity Medicine and cClinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, dSection of Nephrology, Departments of eNeurology and Neurophysiology, fOphthalmology, gClinical Research and hRadiology, University Hospital of North Norway, Tromsø, iDepartment of Ophthalmology, Nordland Hospital, Bodø, and jOslo University Hospital, Oslo, Norway

Related Articles for ""

Nephron 2015;131:175-184

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Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Original Paper

Received: June 03, 2015
Accepted: September 11, 2015
Published online: October 02, 2015
Issue release date: November 2015

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 4

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Background/Aims: Estimated glomerular filtration rate (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR and retinal vasculopathy, a marker of systemic microvasculopathy. Methods: Iohexol clearance and retinal photography were examined in the Renal Iohexol Clearance Survey in Tromsø 6, which consists of a representative sample of middle-aged persons from the general population. A total of 1,553 persons without self-reported kidney disease, cardiovascular disease or diabetes were investigated. Three eGFR equations based on creatinine and/or cystatin C from the Chronic Kidney Disease Epidemiology Collaboration were studied. Differences between eGFR and mGFR were analyzed with seemingly unrelated regression methods. Results: mGFR in the lowest quartile was associated with an increased multivariable-adjusted odds ratio of retinopathy (OR 1.86, 95% CI 1.16-2.97), but not with retinal artery or vein diameters. eGFR based on cystatin C (eGFRcys) was consistently biased relative to mGFR in its associations with retinal vessel diameters across different models. eGFR based on creatinine (eGFRcrea) and eGFR based on both creatinine and cystatin C were also biased in several of these models (p < 0.05). For retinopathy, the differences between the 3 eGFR and mGFR measurements were not statistically significant. Conclusions: Low mGFR is associated with retinopathy in the general population. eGFR based on creatinine and/or cystatin C are not valid substitutes for mGFR in studies of the relationship between the retina and kidney function in healthy persons.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Practice: Original Paper

Received: June 03, 2015
Accepted: September 11, 2015
Published online: October 02, 2015
Issue release date: November 2015

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 4

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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