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Case Report

Free Access

Invasive Squamous Carcinoma and Adenocarcinoma of an Unreconstructed Exstrophic Bladder with HPV Infection

Altan M.a · Çıtamak B.a · Haberal H.B.a · Söğütdelen E.a · Bozaci A.C.a · Baydar D.E.b · Doğan H.S.b · Tekgül S.a

Author affiliations

aDepartment of Urology; and bDeparment of Pathology, Hacettepe University, Ankara, Turkey

Corresponding Author

Hakan Bahadır Haberal

Department of Urology, Hacettepe University Hospital

Ankara (Turkey)

E-Mail bahadirhaberal@gmail.com

Related Articles for ""

Curr Urol 2015;9:109-112

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Abstract

Bladder exstrophy is a complex abnormality and is traditionally treated within the early years of life. It is associated with an increased risk of bladder cancer, with 95% of the arising tumors being adenocarcinomas and 3 to 5% being squamous cell carcinomas. HPV infections are also associated with an increased risk of bladder cancer. This case represents a patient with bladder exstrophy that gave rise to coinciding squamous cell carcinoma and adenocarcinoma. Final pathology results showed an infection with HPV. We presented the management of the case and discussed the diagnosis and treatment methods for this patient.

© 2016 S. Karger AG, Basel


References

  1. Grossfeld GD, Carroll PR: Evaluation of asymptomatic microscopic hematuria. Urol Clin North Am 1998;25:661-676.
  2. Matsuda T, Okada Y, Takeuchi H, Yoshida O: Adult female exstrophy of bladder treated with a Koch continent reservoir: report of a case. Urol Int 1987;42:74-76.
  3. Gulati P, Yadav SP, Sharma U: Management of bladder exstrophy in adulthood: report of 2 cases. J Urol 1997;157:947-948.
  4. Ozdiler E, Sarica K, Baltaci S, Isikay L, Kosar A, Yaman O: A 49-year-old woman with non-complicated exstrophy of bladder. Int Urol Nephrol 1996;28:747-750.
  5. Quattara K, Daffe S, Timbely A: Exstrophy of the bladder in adults. J Urol (Pars) 1992; 98:64-65.
  6. Pathak HR, Mahajan R, Ali NI, Kaul S, Andankar MG: Bladder preservation in adult classic exstrophy: early results of four patients. Urology 2001;57:906-910.
  7. de Riese WD, Warmbold H: Adenocarcinoma in extrophy of the bladder, a case report and review of the literature. Int Urol Nephrol 1986;18:159-162.
  8. Gupta S, Gupta IM: Ectopia vesica complicated by squamous cell carcinoma. Br J Urol 1976;48:224.
  9. Smeulders N, Woodhouse CR: Neoplasia in adult exstrophy patients. BJU Int 2001;87:623-628.
  10. Witters S, Baert-Van Damme L: Bladder exstrophy complicated by adenocarcinoma. Eur Urol 1987;13:415-416.
  11. Rieder JM, Parsons JK, Gearhart JP, Schoenberg M: Primary squamous cell carcinoma in unreconstructed exstrophic bladder. Urology 2006;67:199.
  12. Husmann D, Spence H: Current status of tumor of the bowel following ureterosigmoidostomy: a review. J Urol 1990;144:607-610.
  13. Filmer R, Spencer J: Malignancies in bladder augmentations and intestinal conduits. J Urol 1990;143:671-678.
  14. McIntosh JF, Worley G Jr: Adenocarcinoma arising in exstrophy of the bladder: report of two cases and review of the literature. J Urol 1955;73:820-829.
  15. Husmann DA, Rathbun SR: Long-term follow up of enteric bladder augmentations: the risk for malignancy. J Pediatr Urol 2008;4: 381-385.
  16. Gutierrez J, Jimenez A, de Dios Luna J, Soto MJ, Sorlozano A: Meta-analysis of studies analyzing the relationship between bladder cancer and infection by human papillomavirus. J Urol 2006;176:2474-2481.
  17. Wiwanitkit V: Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. Asian Pac J Cancer Prev 2005; 6:217-218.
  18. Li N, Yang L, Zhang Y, Zhao P, Zheng T, Dai M: Human papillomavirus infection and bladder cancer risk: a meta-analysis. J Infect Dis 2011;204:217-223.

Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: September 01, 2015
Accepted: October 02, 2015
Published online: May 20, 2016
Issue release date: May 2016

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 1661-7649 (Print)
eISSN: 1661-7657 (Online)

For additional information: https://www.karger.com/CUR

References

  1. Grossfeld GD, Carroll PR: Evaluation of asymptomatic microscopic hematuria. Urol Clin North Am 1998;25:661-676.
  2. Matsuda T, Okada Y, Takeuchi H, Yoshida O: Adult female exstrophy of bladder treated with a Koch continent reservoir: report of a case. Urol Int 1987;42:74-76.
  3. Gulati P, Yadav SP, Sharma U: Management of bladder exstrophy in adulthood: report of 2 cases. J Urol 1997;157:947-948.
  4. Ozdiler E, Sarica K, Baltaci S, Isikay L, Kosar A, Yaman O: A 49-year-old woman with non-complicated exstrophy of bladder. Int Urol Nephrol 1996;28:747-750.
  5. Quattara K, Daffe S, Timbely A: Exstrophy of the bladder in adults. J Urol (Pars) 1992; 98:64-65.
  6. Pathak HR, Mahajan R, Ali NI, Kaul S, Andankar MG: Bladder preservation in adult classic exstrophy: early results of four patients. Urology 2001;57:906-910.
  7. de Riese WD, Warmbold H: Adenocarcinoma in extrophy of the bladder, a case report and review of the literature. Int Urol Nephrol 1986;18:159-162.
  8. Gupta S, Gupta IM: Ectopia vesica complicated by squamous cell carcinoma. Br J Urol 1976;48:224.
  9. Smeulders N, Woodhouse CR: Neoplasia in adult exstrophy patients. BJU Int 2001;87:623-628.
  10. Witters S, Baert-Van Damme L: Bladder exstrophy complicated by adenocarcinoma. Eur Urol 1987;13:415-416.
  11. Rieder JM, Parsons JK, Gearhart JP, Schoenberg M: Primary squamous cell carcinoma in unreconstructed exstrophic bladder. Urology 2006;67:199.
  12. Husmann D, Spence H: Current status of tumor of the bowel following ureterosigmoidostomy: a review. J Urol 1990;144:607-610.
  13. Filmer R, Spencer J: Malignancies in bladder augmentations and intestinal conduits. J Urol 1990;143:671-678.
  14. McIntosh JF, Worley G Jr: Adenocarcinoma arising in exstrophy of the bladder: report of two cases and review of the literature. J Urol 1955;73:820-829.
  15. Husmann DA, Rathbun SR: Long-term follow up of enteric bladder augmentations: the risk for malignancy. J Pediatr Urol 2008;4: 381-385.
  16. Gutierrez J, Jimenez A, de Dios Luna J, Soto MJ, Sorlozano A: Meta-analysis of studies analyzing the relationship between bladder cancer and infection by human papillomavirus. J Urol 2006;176:2474-2481.
  17. Wiwanitkit V: Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. Asian Pac J Cancer Prev 2005; 6:217-218.
  18. Li N, Yang L, Zhang Y, Zhao P, Zheng T, Dai M: Human papillomavirus infection and bladder cancer risk: a meta-analysis. J Infect Dis 2011;204:217-223.

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