Cerebrovascular Diseases
Original Paper
High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid EndarterectomyEdsfeldt A.a, b · Bengtsson E.a · Asciutto G.a, c · Dunér P.a · Björkbacka H.a · Fredrikson G.N.a · Nilsson J.a · Goncalves I.a, baDepartment of Clinical Sciences Malmö, Lund University, bDepartment of Cardiology, Skåne University Hospital, Lund, and cVascular Centre, Skåne University Hospital, Malmö, Sweden
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Article / Publication Details
Received: July 03, 2015
Accepted: November 17, 2015
Published online: January 27, 2016
Issue release date: March 2016
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2
ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)
For additional information: https://www.karger.com/CED
Abstract
Background: Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properties. High plasma Gal-3 levels are associated with increased risk for cardiovascular (CV) death. However, it has so far not been investigated if plasma Gal-3 levels can predict the risk for future stroke in patients suffering from carotid atherosclerosis. The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA). Methods: Plasma samples were obtained from 558 CEA patients and Gal-3 levels were analyzed by the proximity extension assay technique. The Swedish national in-patient health register was used to identify postoperative cerebrovascular events during the follow-up period (42.6 ± 26.2 months). Results: Plasma Gal-3 was increased in patients treated for a symptomatic carotid stenosis (p = 0.013). Patients with Gal-3 levels above the median value had an increased incidence of stroke as shown by Kaplan-Meier curves of event-free survival (p = 0.007). Gal-3 was a predictor of postoperative stroke among women (hazard ratio 15.1, 95% CI 1.3-172.2; p = 0.028) even after correction for traditional CV risk factors. Conclusions: This study is the first to show that increased plasma levels of Gal-3 can help in predicting the occurrence of postoperative strokes among female subjects who undergo CEA, independently of traditional risk factors for cerebrovascular disease. This finding suggests that Gal-3 could be used as a marker to identify patients in need of intensified postoperative medical care.
© 2016 S. Karger AG, Basel
References
-
Liu FT, Rabinovich GA: Galectins: regulators of acute and chronic inflammation. Ann N Y Acad Sci 2010;1183:158-182.
-
Yang RY, Rabinovich GA, Liu FT: Galectins: structure, function and therapeutic potential. Expert Rev Mol Med 2008;10:e17.
-
Al-Ansari S, Zeebregts CJ, Slart RH, Peppelenbosch M, Tio RA: Galectins in atherosclerotic disease. Trends Cardiovasc Med 2009;19:164-169.
-
de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege HL, et al: The fibrosis marker galectin-3 and outcome in the general population. J Intern Med 2012;272:55-64.
-
Madrigal-Matute J, Lindholt JS, Fernandez-Garcia CE, Benito-Martin A, Burillo E, Zalba G, et al: Galectin-3, a biomarker linking oxidative stress and inflammation with the clinical outcomes of patients with atherothrombosis. J Am Heart Assoc 2014;3:pii:e000785.
-
Rattik S, Wigren M, Björkbacka H, Fredrikson GN, Hedblad B, Siegbahn A, et al: High plasma levels of heparin-binding epidermal growth factor are associated with a more stable plaque phenotype and reduced incidence of coronary events. Arterioscler Thromb Vasc Biol 2015;35:222-228.
-
Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, et al: External review and validation of the Swedish national inpatient register. BMC Public Health 2011;11:450.
-
Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, et al: Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:227-276.
Article / Publication Details
Received: July 03, 2015
Accepted: November 17, 2015
Published online: January 27, 2016
Issue release date: March 2016
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2
ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)
For additional information: https://www.karger.com/CED
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