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Review

The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review

Lobo S.E.a, c · Leonel L.C.P.C.a · Miranda C.M.F.C.a · Coelho T.M.d · Ferreira G.A.S.e · Mess A.a · Abrão M.S.c · Miglino M.A.a, b

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aDepartment of Surgery, Sector of Anatomy, School of Veterinary Medicine and Animal Science and bNETCEM - Center for Cellular and Molecular Studies and Therapy, Universidade de São Paulo, cDepartment of Obstetrics and Gynecology, University of São Paulo School of Medicine, dUniversidade Metodista de São Paulo, and eUniversidade São Judas Tadeu, São Paulo, Brazil

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Cells Tissues Organs 2015–16;201:239–252

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Article / Publication Details

First-Page Preview
Abstract of Review

Accepted: December 22, 2015
Published online: April 07, 2016
Issue release date: May 2016

Number of Print Pages: 14
Number of Figures: 6
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO

Abstract

The placenta is a temporal, dynamic and diverse organ with important immunological features that facilitate embryonic and fetal development and survival, notwithstanding the fact that several aspects of its formation and function closely resemble tumor progression. Placentation in mammals is commonly used to characterize the evolution of species, including insights into human evolution. Although most placentas are discarded after birth, they are a high-yield source for the isolation of stem/progenitor cells and are rich in extracellular matrix (ECM), representing an important resource for regenerative medicine purposes. Interactions among cells, ECM and bioactive molecules regulate tissue and organ generation and comprise the foundation of tissue engineering. In the present article, differences among several mammalian species regarding the placental types and classifications, phenotypes and potency of placenta-derived stem/progenitor cells, placental ECM components and current placental ECM applications were reviewed to highlight their potential clinical and biomedical relevance.

© 2016 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Accepted: December 22, 2015
Published online: April 07, 2016
Issue release date: May 2016

Number of Print Pages: 14
Number of Figures: 6
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO


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