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Clinical Study

Pregnancy in a Series of Dystonia Patients Treated with Deep Brain Stimulation: Outcomes and Management Recommendations

Ziman N.a · Coleman R.R.a · Starr P.A.b · Volz M.a · Marks Jr. W.J.a · Walker H.C.c, d · Guthrie S.L.c · Ostrem J.L.a

Author affiliations

aDepartment of Neurology, University of California, San Francisco, Movement Disorder and Neuromodulation Center, and bDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, Calif., and Departments of cNeurology and dBiomedical Engineering, University of Alabama at Birmingham, Birmingham, Ala., USA

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 28, 2015
Accepted: January 26, 2016
Published online: March 16, 2016
Issue release date: April 2016

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Background: Medically refractory dystonia affects children and young adults, and deep brain stimulation (DBS) can allow some patients to regain functional independence. Women with dystonia treated with DBS may wish to conceive a child, but there is limited published information on pregnancy and DBS. Objective: To describe a series of dystonia patients treated with DBS who later became pregnant and provide guidelines for women treated with DBS considering conception. Methods: We reviewed all dystonia DBS cases implanted at the University of California, San Francisco, and University of Alabama at Birmingham from 1998 to 2015 and identified patients who became pregnant. Patient records were reviewed and structured interviews were conducted. Results: Six dystonia patients were identified [1 currently pregnant and 7 live births (including 1 twin pair)]. Patients (n = 5) with pre- and postoperative BFMDRS (Burke-Fahn-Marsden Dystonia Rating Scale) scores improved by 65.9% after DBS. All pregnancies and deliveries were uncomplicated (the delivery mode was not influenced by the presence of DBS), except for 1 child, who was born premature at 35 weeks' gestation. Stimulation remained on (n = 3) or off (n = 4) during deliveries. DBS neurostimulators did not hinder breastfeeding. Conclusions: In this small sample, pregnancy, delivery, and breastfeeding were safe in dystonia patients treated with DBS. The presence of DBS should not be a contraindication to pregnancy.

© 2016 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 28, 2015
Accepted: January 26, 2016
Published online: March 16, 2016
Issue release date: April 2016

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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