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Clinical Investigations

Free Access

Methods for Measuring Lung Volumes: Is There a Better One?

Tantucci C.a · Bottone D.a · Borghesi A.b · Guerini M.a · Quadri F.a · Pini L.a

Author affiliations

aRespiratory Medicine Unit, Department of Clinical and Experimental Sciences, and bDepartment of Radiology, University of Brescia, Brescia, Italy

Corresponding Author

Dr. Laura Pini

Scienze Cliniche e Sperimentali, II Divisione di Medicina

Università degli Studi di Brescia, P.le Spedali Civili, 1

IT-25123 Brescia (Italy)

E-Mail laura.pini@unibs.it

Related Articles for ""

Respiration 2016;91:273-280

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Abstract

Background: Accurate measurement of lung volumes is of paramount importance to establish the presence of ventilatory defects and give insights for diagnostic and/or therapeutic purposes. Objectives: It was the aim of this study to measure lung volumes in subjects with respiratory disorders and in normal controls by 3 different techniques (plethysmographic, dilutional and radiographic methods), in an attempt to clarify the role of each of them in performing such a task, without any presumptive ‘a priori' superiority of one method above others. Patients andMethods: In different groups of subjects with obstructive and restrictive ventilatory defects and in a normal control group, total lung capacity, functional residual capacity (FRC) and residual volume were measured by body plethysmography, multi-breath helium (He) dilution and radiographic CT scan method with spirometric gating. Results: The 3 methods gave comparable results in normal subjects and in patients with a restrictive defect. In patients with an obstructive defect, CT scan and plethysmography showed similar lung volumes, while on average significantly lower lung volumes were obtained with the He dilution technique. Taking into account that the He dilution technique does primarily measure FRC during tidal breathing, our data suggest that in some patients with an obstructive defect, a number of small airways can be functionally closed at end-expiratory lung volume, preventing He to reach the lung regions subserved by these airways. Conclusion: In all circumstances, both CT scan with spirometric gating and plethysmographic methods provide similar values of lung volumes. In contrast, the He dilution method can measure lower lung volumes in some patients with chronic airflow obstruction.

© 2016 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: August 10, 2015
Accepted: February 02, 2016
Published online: March 17, 2016
Issue release date: May 2016

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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