Caries Research

Current Topic

On the Etiology of Molar-Incisor Hypomineralization

Vieira A.R.a · Kup E.b

Author affiliations

aDepartment of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA; bPrivate Practice, São Paulo, Brazil

Keywords: Dental enamelEnamel hypoplasiaGenetics

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Caries Res 2016;50:166-169
https://doi.org/10.1159/000445128

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Article / Publication Details

First-Page Preview
Abstract of Current Topic

Received: February 23, 2016
Accepted: February 29, 2016
Published online: April 26, 2016
Issue release date: May 2016

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

Abstract

Molar-incisor hypomineralization (MIH) is a condition that is defined based on its peculiar clinical presentation. Reports on the etiology of the condition and possible risk factors are inconclusive and the original suggestion that MIH is an idiopathic condition is often cited. Our group was the first to suggest MIH has a genetic component that involves genetic variation in genes expressed during dental enamel formation. In this report, we provide a rationale to explain the preferential affection of molars and incisors. We suggest that MIH is a genetic condition based on its prevalence, which varies depending on the geographic location, and the evidence that on occasion second primary molars, permanent canines, and premolars can show signs of hypomineralization of enamel when molars and incisors are affected.

© 2016 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Current Topic

Received: February 23, 2016
Accepted: February 29, 2016
Published online: April 26, 2016
Issue release date: May 2016

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

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2016, Vol.50, No. 2

May 2016

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