Cerebrovascular Diseases

Original Paper

Visceral Fat Is an Independent Predictor of Cerebral Microbleeds in Neurologically Healthy People

Kwon H.-M.a · Park J.-H.c · Park J.H.b · Jeong H.-Y.d · Lim J.-S.a, e · Jeong H.-G.a · Shin D.W.b · Yun J.M.b · Lee H.b

Author affiliations

aDepartment of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, and bDepartment of Family Medicine, Seoul National University Hospital, Seoul, cDepartment of Neurology, Myongji Hospital, Goyang, dDepartment of Neurology, Aerospace Medical Center, Cheongju, and eDepartment of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea

Keywords: Cerebral small vessel diseasesMRIObesity

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Cerebrovasc Dis 2016;42:90-96
https://doi.org/10.1159/000445300

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 16, 2015
Accepted: March 07, 2016
Published online: April 13, 2016
Issue release date: June 2016

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

Background: Obesity has a significant contribution to the risk of intracerebral hemorrhage (ICH). However, little is known about the association between central obesity and the presence of cerebral microbleeds (CMBs), a precursor of ICH. We sought to assess whether visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are associated with the presence of CMB. Methods: We conducted a cross-sectional study of 1,737 neurologically healthy people (mean age 55.9 ± 9.1; 790 men), who underwent brain MRI and abdominal CT. Risk factors, anthropometric parameters and clinical information were obtained. CMBs were evaluated through T2*-weighted gradient-recalled echo MRI. The cross-sectional surface areas of the abdominal fat compartments were calculated. Study subjects were stratified into quartiles according to the distribution of VAT/SAT ratio. Results: A total of 75 (4.3%) subjects were found to have CMBs. Subjects with a greater quartile of VAT/SAT ratio were more likely to have higher numbers of CMBs (0 to ≥2; p = 0.001). In multivariable analysis, age and history of hypertension were associated with the presence of CMB (OR 1.09, 95% CI 1.06-1.13, p < 0.001; OR 1.70, 95% CI 1.01-2.84, p = 0.046, respectively). A dose-response relationship was observed between the extent of VAT/SAT quartile and CMB: compared to the lowest VAT/SAT quartile, OR 2.14 (95% CI 0.86-5.35) for second VAT/SAT quartile; OR 2.26 (95% CI 0.86-5.92) for third VAT/SAT quartile; and OR 2.91 (95% CI 1.04-8.12) for the highest VAT/SAT quartile (p for trend 0.03). Conclusion: In our study, higher VAT/SAT ratios were found to be independent predictors of CMBs in neurologically healthy people. This finding strengthens previous data, suggesting that visceral fat distribution is an important contributor to cerebral small vessel disease.

© 2016 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 16, 2015
Accepted: March 07, 2016
Published online: April 13, 2016
Issue release date: June 2016

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

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2016, Vol.42, No. 1-2

June 2016

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