Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study

Hursh B.E.a-c · Fazeli M.S.b-d · Wang S.d · Marchant E.A.c, d · Woo P.a · Elango R.b, c · Lavoie P.M.b, c · Chanoine J.-P.a, b · Collet J.-P.b, c

Author affiliations

aEndocrinology and Diabetes Unit, BC Children's Hospital, bDepartment of Pediatrics, The University of British Columbia, cChild and Family Research Institute, and dFaculty of Medicine, The University of British Columbia, Vancouver, B.C., Canada

Related Articles for ""

Horm Res Paediatr 2016;85:339-346

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 11, 2016
Accepted: March 18, 2016
Published online: April 23, 2016
Issue release date: June 2016

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

Background/Aims: The autonomic nervous system (ANS) provides neurogenic control of inflammatory reactions. ANS changes in obesity may result in inflammation. This study sought to gain insight into cardiac autonomic dysfunction and inflammation in childhood obesity, and to gather pilot data on the potential relationship between altered ANS and inflammation. Methods: Fifteen obese children and adolescents without metabolic complications and 15 nonobese controls underwent heart rate variability and impedance cardiography testing during rest, mental stress, and physical stress. Inflammatory cytokines and immune reactivity were measured. Results: There was no statistically significant difference between groups in cardiac ANS testing at rest or in response to stress. Median high-sensitivity C-reactive protein (hsCRP) was higher in the obese group [obese 2.6 mg/l (IQR 1.6-11.9); nonobese 0.3 mg/l (IQR 0.2-0.7); p < 0.001]. Interleukin-6 and tumour necrosis factor-α were similar between groups. Immune reactivity testing (in vitro Toll-like receptor stimulation) revealed a strong, but comparable, inflammatory response in both groups. Conclusions: Obese children and adolescents without metabolic complications did not have cardiac ANS dysfunction. While hsCRP was elevated, systemic cytokines were not raised. Compared to prior studies, which often focused on children with obesity and its complications, it is encouraging that obese children without metabolic complications may not yet have autonomic dysfunction.

© 2016 S. Karger AG, Basel


References

  1. Vinik AI, Maser RE, Ziegler D: Autonomic imbalance: prophet of doom or scope for hope? Diabet Med 2011;28:643-651.
  2. Emdin M, Gastaldelli A, Muscelli E, Macerata A, Natali A, Camastra S, et al: Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss. Circulation 2001;103:513-519.
  3. Manzella D, Barbieri M, Rizzo MR, Ragno E, Passariello N, Gambardella A, et al: Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: effects of metabolic control. J Clin Endocrinol Metab 2014;86.
  4. Vinik AI, Maser RE, Mitchell BD, Freeman R: Diabetic autonomic neuropathy. Diabetes Care 2003;26:1553-1579.
  5. Dangardt F, Volkmann R, Chen Y, Osika W, Mårild S, Friberg P: Reduced cardiac vagal activity in obese children and adolescents. Clin Physiol Funct Imaging 2011;31:108-113.
  6. Beijers H, et al: Microalbuminuria and cardiovascular autonomic dysfunction are independently associated with cardiovascular mortality: evidence for distinct pathways. Diabetes Care 2009;32:1698-1703.
  7. Gerritsen J: Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease. Diabetes Care 2001;24:1793-1798.
  8. Eyre ELJ, Duncan MJ, Birch SL, Fisher JP: The influence of age and weight status on cardiac autonomic control in healthy children: a review. Auton Neurosci Basic Clin 2014;186C:8-21.
  9. Rodríguez-Colón SM, Bixler EO, Li X, Vgontzas AN, Liao D: Obesity is associated with impaired cardiac autonomic modulation in children. Int J Pediatr Obes 2011;6:128-134.
  10. Thorp AA, Schlaich MP: Relevance of sympathetic nervous system activation in obesity and metabolic syndrome. J Diabetes Res 2015;2015:341583.
  11. Rosas-Ballina M, Tracey KJ: Cholinergic control of inflammation. J Intern Med 2009;265:663-679.
  12. Huston JM, Tracey KJ: The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy. J Intern Med 2011;269:45-53.
  13. Bondia-Pons I, Ryan L, Martinez JA: Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 2012;68:701-711.
  14. DeBoer MD: Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions. Nutrition 2013;29:379-386.
  15. Taşçılar ME, Yokuşoğlu M, Boyraz M, Baysan O, Köz C, Dündaröz R: Cardiac autonomic functions in obese children. J Clin Res Pediatr Endocrinol 2011;3:60-64.
  16. Cohen S, Kamarck T, Mermelstein R: A global measure of perceived stress. J Health Soc Behav 1983;24:385-396.
    External Resources
  17. Schaefer F, Georgi M, Zieger A, Schärer K: Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res 1994;35:617-624.
  18. Wabitsch M, Braun U, Heinze E, Muche R, Mayer H, Teller W, et al: Body composition in 5-18-y-old obese children and adolescents before and after weight reduction as assessed by deuterium dilution and bioelectrical impedance analysis. Am J Clin Nutr 1996;64:1-6.
    External Resources
  19. Marchant EA, Kan B, Sharma AA, van Zanten A, Kollmann TR, Brant R, et al: Attenuated innate immune defenses in very premature neonates during the neonatal period. Pediatr Res 2015;78:492-497.
  20. Lind AR, McNicol GW: Circulatory responses to sustained hand-grip contractions. JPhysiol 1967;192:595-607.
  21. Malik M, Bigger J, Camm A, Kleiger R: Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996;17:354-381.
    External Resources
  22. Newlin DB, Levenson RW: Pre-ejection period: measuring beta-adrenergic influences upon the heart. Psychophysiology 1979;16:546-553.
  23. Martini G, Riva P, Rabbia F, Molini V, Ferrero GB, Cerutti F, et al: Heart rate variability in childhood obesity. Clin Auton Res 2001;11:87-91.
  24. Riva P, Martini G, Rabbia F, Milan A, Paglieri C, Chiandussi L, et al: Obesity and autonomic function in adolescence. Clin Exp Hypertens 2001;23:57-67.
  25. Kaufman CL, Kaiser DR, Steinberger J, Kelly AS, Dengel DR: Relationships of cardiac autonomic function with metabolic abnormalities in childhood obesity. Obesity 2007;15:1164-1171.
  26. Baum P, Petroff D, Classen J, Kiess W, Blüher S: Dysfunction of autonomic nervous system in childhood obesity: a cross-sectional study. PLoS One 2013;8:e54546.
  27. Rabbia F, Silke B, Conterno A, Grosso T, De Vito B, Rabbone I, et al: Assessment of cardiac autonomic modulation during adolescent obesity. Obes Res 2003;11:541-548.
  28. Nagai N, Moritani T: Effect of physical activity on autonomic nervous system function in lean and obese children. Int J Obes Relat Metab Disord 2004;28:27-33.
  29. Tonhajzerova I, Javorka M, Trunkvalterova Z, Chroma O, Javorkova J, Lazarova Z, et al: Cardio-respiratory interaction and autonomic dysfunction in obesity. J Physiol Pharmacol 2008;59:709-718.
    External Resources
  30. Vanderlei LCM, Pastre CM, Freitas Júnior IF, de Godoy MF: Analysis of cardiac autonomic modulation in obese and eutrophic children. Clinics 2010;65:789-792.
  31. Guízar J, Ahuatzin R, Amador N, Sánchez G, Romer G: Heart autonomic function in overweight adolescents. Indian Pediatr 2005;42:464-469.
    External Resources
  32. Sekine M, Izumi I, Yamagami T, Kagamimori S: Obesity and cardiac autonomic nerve activity in healthy children: results of the Toyama birth cohort study. Environ Health Prev Med 2001;6:149-153.
  33. Yakinci C, Mungen B, Karabiber H, Tayfun M, Evereklioglu C: Autonomic nervous system functions in obese children. Brain Dev 2000;22:151-153.
  34. Cozzolino D, Esposito K, Palmiero G, De Bellis A, Furlan R, Perrotta S, et al: Cardiac autonomic regulation in response to a mixed meal is impaired in obese children and adolescents: the role played by insulin resistance. J Clin Endocrinol Metab 2014;99:3199-3207.
  35. Latchman PL, Mathur M, Bartels MN, Axtell RS, De Meersman RE: Impaired autonomic function in normotensive obese children. Clin Auton Res 2011;21:319-323.
  36. Freitas IMG, Miranda JA, Mira PAC, Lanna CMM, Lima JRP, Laterza MC: Cardiac autonomic dysfunction in obese normotensive children and adolescents. Rev Paul Pediatr 2014;32:244-249.
  37. Rodríguez-Colón SM, He F, Bixler EO, Fernandez-Mendoza J, Vgontzas AN, Calhoun S, et al: Metabolic syndrome burden in apparently healthy adolescents is adversely associated with cardiac autonomic modulation - Penn State Children Cohort. Metabolism 2015;4:625-632.
  38. Nie JX, Ardern CI: Association between obesity and cardiometabolic health risk in Asian-Canadian sub-groups. PLoS One 2014;9:21-23.
  39. Schipper HS, Nuboer R, Prop S, Van Den Ham HJ, De Boer FK, Kesmir Ç, et al: Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes. Diabetologia 2012;55:2800-2810.
  40. Kim J, Bhattacharjee R, Kheirandish-Gozal L, Khalyfa A, Sans Capdevila O, Tauman R, et al: Insulin sensitivity, serum lipids, and systemic inflammatory markers in school-aged obese and nonobese children. Int J Pediatr 2010;2010:846098.
  41. Frühbeck G: Vasoactive factors and inflammatory mediators produced in adipose tissue; in Fantuzzi G, Mazzone T (eds): Adipose Tissue and Adipokines in Health and Disease. Totowa, Human Press, Inc., 2007, pp 63-77.
    External Resources
  42. Bing C: Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity? Adipocyte 2015;4:149-152.
  43. Lee BC, Lee J: Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta - Mol Basis Dis 2014;1842:446-462.
  44. Vitale M, Masulli M, Rivellese AA, Babini AC, Boemi M, Bonora E, et al: Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes - The TOSCA.IT Study. Eur J Nutr 2015, DOI: 10.1007/s00394-015-0983-1.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 11, 2016
Accepted: March 18, 2016
Published online: April 23, 2016
Issue release date: June 2016

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.