Cardiology

Original Research

Matrix Metalloproteinase-9 as a Marker for Plaque Rupture and a Predictor of Adverse Clinical Outcome in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study

Kobayashi N.a · Takano M.b · Hata N.a · Kume N.c · Tsurumi M.a · Shirakabe A.a · Okazaki H.a · Shibuya J.a · Shiomura R.a · Nishigoori S.a · Seino Y.b · Shimizu W.d

Author affiliations

aIntensive Care Unit and bDepartment of Cardiology, Nippon Medical School, Chiba Hokusoh Hospital, Chiba, cDivision of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, and dDepartment of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan

Keywords: Optical coherence tomographyRuptured plaquesBiomarkerMatrix metalloproteinase-9

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Cardiology 2016;135:56-65
https://doi.org/10.1159/000445994

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: January 29, 2016
Accepted: April 06, 2016
Published online: June 07, 2016
Issue release date: August 2016

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Objectives: The present study sought to clarify the relationship between matrix metalloproteinase-9 (MMP-9) levels and plaque morphology demonstrated by optical coherence tomography (OCT), and to examine their prognostic impacts in patients with acute coronary syndrome (ACS). Methods: MMP-9 levels were measured for patients with ACS (n = 249). Among 249 patients, 120 with evaluable OCT images were categorized into patients with ruptured plaques (n = 65) and those with nonruptured plaques (n = 55) on the basis of culprit lesion plaque morphology demonstrated by OCT. Results: MMP-9 levels on admission were significantly higher in the rupture group than in the nonrupture group (p = 0.029). Although creatine kinase-MB (CK-MB) on admission was comparable between the groups, peak CK-MB was higher in the rupture group than in the nonrupture group (p < 0.001). By receiver operating characteristic curve analysis, the optimal cut-off value of MMP-9 to detect ruptured plaques was 65.5 ng/ml (p = 0.029). There was a nonstatistically significant trend toward increased cardiac death at 2 years (5.9 vs. 1.0%, p = 0.059) in patients with high MMP-9 (≥65.5 ng/ml) compared to those with low MMP-9 (<65.5 ng/ml). Conclusions: MMP-9 can differentiate ACS with ruptured plaques from nonruptured plaques, and MMP-9 may be a valuable predictor of long-term cardiac mortality in patients with ACS reflecting plaque rupture.

© 2016 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: January 29, 2016
Accepted: April 06, 2016
Published online: June 07, 2016
Issue release date: August 2016

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

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