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Clinical Study

Deep Brain Stimulation for Status Dystonicus: A Case Series and Review of the Literature

Ben-Haim S.a · Flatow V.a · Cheung T.c · Cho C.b · Tagliati M.c · Alterman R.L.d

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Departments of aNeurosurgery and bNeurology, Mount Sinai Hospital, New York, N.Y., cDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, Calif., and dDepartment of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, Mass., USA

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Stereotact Funct Neurosurg 2016;94:207-215

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 27, 2015
Accepted: April 14, 2016
Published online: August 10, 2016
Issue release date: October 2016

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 5

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Background: Status dystonicus (SD) is a rare and potentially life-threatening complication of primary or secondary dystonia, characterized by acute worsening of dystonic movements. There is no consensus regarding optimal treatment, which may be medical and/or surgical. Methods: We present our experience with pallidal deep brain stimulation (DBS) in 5 DYT1-positive patients with SD and provide a review of the literature to examine optimal management. Results: Of the 5 patients treated with pallidal DBS, all experienced postoperative resolution of their dystonic crisis within a range of 1-21 days. Long-term follow-up resulted in 1 patient returning to preoperative baseline, 3 patients improving from baseline, and 1 patient making a complete recovery. Of the 28 SD patients (including our 5 patients) reported in the literature who were treated with DBS or ablative surgery, 26 experienced cessation of their dystonic crisis with a return to baseline function and, in most cases, clinical improvement. Conclusion: DBS is an effective therapeutic modality for the treatment of SD. In addition to the long-term benefits of stimulation, early and aggressive treatment may improve the overall outcome.

© 2016 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 27, 2015
Accepted: April 14, 2016
Published online: August 10, 2016
Issue release date: October 2016

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 5

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN


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