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Review Article

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Palbociclib: First CDK4/6 Inhibitor in Clinical Practice for the Treatment of Advanced HR-Positive Breast Cancer

Ettl J.

Author affiliations

Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

Corresponding Author

Dr. med. Johannes Ettl

Frauenklinik und Poliklinik, Klinikum Rechts der Isar

Technische Universität München

Ismaningerstrasse 22, 81675 Munich, Germany


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Breast Care 2016;11:174-176

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Palbociclib is the first inhibitor of the cyclin-dependent kinases (CDK) 4 and 6 to be introduced into clinical practice. Preclinical investigations led to its clinical development in advanced hormone receptor (HR)-positive breast cancer. To date, 2 significant clinical trials have been fully published. In this article, the results of these trials and their clinical relevance for the management of HR-positive advanced breast cancer are discussed.

© 2016 S. Karger GmbH, Freiburg


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: June 23, 2016
Issue release date: June 2016

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: https://www.karger.com/BRC

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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