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Editorial

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The Role of CDK 4/6 Inhibitors in Breast Cancer Treatment

Witzel I. · Müller V.

Author affiliations

Clinic for Gynecology and Obstetrics, University Medical Center Hamburg, Hamburg, Germany

Corresponding Author

PD Dr. med. Isabell Witzel

Clinic for Gynecology and Obstetrics

University Medical Center Hamburg

Martinistraße 52, 20246 Hamburg, Germany

iwitzel@uke.de

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Abstract of Editorial

References

  1. Smith IE, Dowsett M: Aromatase inhibitors in breast cancer. N Engl J Med 2003;348:2431-2442.
  2. Chia S, Gradishar W, Mauriac L, Bines J, Amant F, Federico M, Fein L, Romieu G, Buzdar A, Robertson JF, Brufsky A, Possinger K, Rennie P, Sapunar F, Lowe E, Piccart M: Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. J Clin Oncol 2008;26:1664-1670.
  3. Bosco EE, Wang Y, Xu H, Zilfou JT, Knudsen KE, Aronow BJ, Lowe SW, Knudsen ES: The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest 2007;117:218-228.
  4. Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D: Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol 2016; DOI: 10.1016/S1470-2045(15)00613-0.
  5. Harbeck N, Iyer S, Turner N, Cristofanilli M, Ro J, Andre F, Loi S, Verma S, Iwata H, Bhattacharyya H, Puyana Theall K, Bartlett CH, Loibl S: Quality of life with palbociclib plus fulvestrant in previously treated hormone receptor-positive, HER2-negative metastatic breast cancer: patient-reported outcomes from the PALOMA-3 trial. Ann Oncol 2016; doi: 10.1093/annonc/mdw139.
  6. Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, Ettl J, Patel R, Pinter T, Schmidt M, Shparyk Y, Thummala AR, Voytko NL, Fowst C, Huang X, Kim ST, Randolph S, Slamon DJ: The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol 2015;16:25-35.
  7. Finn et al. PALOMA-2: Primary results from a phase III trial of palbociclib (P) with letrozole (L) compared with letrozole alone in postmenopausal women with ER+/HER2- advanced breast cancer (ABC). J Clin Oncol 2016;34 (suppl) abstr 507.
  8. Schmidt M: Palbociclib - from bench to bedside and beyond. Breast Care 2016; DOI: 10.1159/000447001.
    External Resources
  9. Ettl J: Palbociclib: First CDK4/6 Inhibitor in clinical practice for the treatment of advanced HR-positive breast cancer. Breast Care 2016; DOI: 10.1159/ 000447417.
    External Resources
  10. Barroso-Sousa R, Shapiro GI, Tolaney SM: Clinical development of the CDK4/6 inhibitors ribociclib and abemaciclib in breast cancer. Breast Care 2016; DOI: 10.1159/000447284.
    External Resources

Article / Publication Details

Published online: June 22, 2016
Issue release date: June 2016

Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: https://www.karger.com/BRC


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