Hormone Research in Paediatrics

Original Paper

Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease

Larizza D.a, b · De Amici M.c · Klersy C.d · Albanesi M.a, b · Albertini R.e · Badulli C.e · Torre C.c · Calcaterra V.a, b

Author affiliations

aDepartment of Internal Medicine, University of Pavia, and bDepartment of Maternal and Children's Health, Pediatric Endocrinology Unit, bImmuno-Allergy Laboratory of the Pediatric Clinic, cBiometry and Clinical Epidemiology, Scientific Direction, and dLaboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Keywords: Autoimmune thyroiditisZnT8Type 1 diabetes mellitusCeliac diseaseScreening

Related Articles for ""
Horm Res Paediatr 2016;86:100-105
https://doi.org/10.1159/000448003

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 03, 2016
Accepted: June 24, 2016
Published online: August 03, 2016
Issue release date: October 2016

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

Background/Aims: Patients with type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (ATD), and celiac disease (CD) are at increased risk for developing other autoimmune diseases. We evaluated zinc transporter 8 (ZnT8) prevalence in patients with ATD and/or CD in order to define the usefulness of ZnT8 autoantibodies for prediabetes screening. Methods: Eighty-one young patients with ATD and/or CD were included in the study; 32 subjects with clinical onset of T1DM were enrolled as a control group. GAD65, IA-2, and ZnT8 antibodies were measured. An intravenous glucose tolerance test, C-peptide, glycosylated hemoglobin levels, and genomic analysis of HLA-DQA1* and -DQB1* were also considered in patients positive for autoantibodies. Results: The ZnT8 prevalence was higher in T1DM patients than in patients with other autoimmune diseases (p < 0.001); positive ZnT8 detection was found in 2 ATD (p = 0.004) and 3 ATD + CD (p = 0.04) patients. Positive ZnT8 was associated with GAD65 (p = 0.01) but not with IA-2 positivity. No correlation between ZnT8 detection and the number of T1DM-susceptible HLA-DQ heterodimers was found. Pathological C-peptide levels and insulin response were found in subjects with islet autoimmunity and genetic susceptibility. Conclusion: ZnT8 autoantibodies detection in ATD and/or CD patients is low, and routine ZnT8 screening is not justified. ZnT8 evaluation may be recommended in subjects with autoimmune diseases as a marker for predicting compromised insulin secretion.

© 2016 S. Karger AG, Basel

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 03, 2016
Accepted: June 24, 2016
Published online: August 03, 2016
Issue release date: October 2016

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

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2016, Vol.86, No. 2

October 2016

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