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Short Communication

Editor's Choice - Free Access

Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome

Wada T. · Matsuda Y. · Toma T. · Koizumi E. · Okamoto H. · Yachie A.

Author affiliations

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Corresponding Author

Correspondence to: Dr. Taizo Wada

Department of Pediatrics, School of Medicine

Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

13-1 Takaramachi, Kanazawa 920-8641 (Japan)

E-Mail taizo@staff.kanazawa-u.ac.jp

Related Articles for ""

Int Arch Allergy Immunol 2016;170:201-205

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Background: Food protein-induced enterocolitis syndrome (FPIES) is an uncommon, non-IgE-mediated food allergy. We recently described a significant increase in fecal eosinophil-derived neurotoxin (EDN) after ingestion of the causative food. However, little is known about the activation status of circulating eosinophils in patients with an acute FPIES reaction. Methods: Surface CD69 expression was assessed by flow cytometry on peripheral eosinophils from 5 patients with FPIES before and after ingestion of the causative food. Fecal EDN was measured by enzyme-linked immunosorbent assay. Results: No eosinophil activation was observed before ingestion; however, a significant increase in CD69 expression on eosinophils after an acute FIPES reaction was demonstrated in all of the patients. There was no significant change in absolute eosinophil counts in the peripheral blood. The levels of fecal EDN increased on the day after ingestion of the causative food in all patients. Conclusion: These results suggest that circulating eosinophils as well as eosinophils in the intestinal mucosal tissue are activated in acute FPIES reactions and might be associated with systemic immune events in FPIES.

© 2016 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: April 14, 2016
Accepted: July 27, 2016
Published online: September 06, 2016
Issue release date: September 2016

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

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