Glioblastoma Multiforme Developed during Chronic Deep Brain Stimulation for Parkinson DiseaseYamamoto T.a · Fukaya C.a · Obuchi T.b · Watanabe M.b · Ohta T.b · Kobayashi K.b · Oshima H.b · Yoshino A.b
Divisions of aApplied System Neuroscience and bNeurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background: In this reported case, 7 years after the start of deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN), glioblastoma multiforme (GBM) developed around the implanted DBS lead. Case Report: The brain tumor formed from the subcortical white matter to the corpus callosum bilaterally around the DBS lead but did not extend in the direction of the contact points of the lead. The GBM showed a typical invasion pattern of the butterfly type. We report the first case of GBM that developed 7 years after the start of STN-DBS. Conclusion: Considering the low rate of GBM occurrence in association with DBS, the location of the glioma, and the pattern of tumor invasion, we speculate that GBM developed spontaneously and extended to some degree around the DBS lead. Moreover, there is a very slight possibility that continuous electrical brain stimulation itself induced the development of the brain glioma.
© 2016 S. Karger AG, Basel
- Tsang RW, Laperriere NJ, Simpson WJ, Brierley J, Panzarella T, Smyth HS: Glioma arising after radiation therapy for pituitary adenoma. Cancer 1993;72:2227-2233.
- Shamisa A, Bance M, Nag S,Tator C, Wong S, Guha A: Glioblastoma multiforme occurring in a patient treated with gamma knife surgery. J Neurosurg 2001;94:816-821.
Medtronic Press Release. http://newsroom.medtronic.com/phoenix.zhtml?c=251324 &p=irol-newsArticle&ID=2038656.
- Dziurzynski K, Blas-Boria D, Suki D, Cahill DP, Prabhu SS, Puduvalli V, Levine N: Butterfly glioblastomas: a retrospective review and qualitative assessment of outcomes. J Neurooncol 2012;109:555-563.
- Karipidis KK, Benke G, Sim MR, Yost M, Giles G: Occupational exposure to low-frequency magnetic fields and the risk of low-grade and high-grade glioma. Cancer Causes Control 2007;18:305-313.
- Klaeboe L, Blaasaas KG, Haldorsen T, Tynes T: Residential and occupational exposure to 50-Hz magnetic fields and brain tumors in Norway: a population-based study. Int J Cancer 2005;20:137-141.
- Sorahan T: Magnetic fields and brain tumor risks in UK electricity supply workers. Occup Med (Lond) 2014;64:157-165.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.