Nephron

Original Paper

Urinary Excretion of Tamm-Horsfall Protein and Epidermal Growth Factor in Chronic Nephropathy

Torffvit O.a · Jørgensen P.E.b · Kamper A.-L.c · Holstein-Rathlou N.-H.d · Leyssac P.P.d · Poulsen S.S.e · Strandgaard S.c

Author affiliations

aDepartment of Internal Medicine, University Hospital of Lund, Sweden; b Department of Clinical Biochemistry, KH University Hospital of Aarhus, c Department of Nephrology, Herlev Hospital, University of Copenhagen, d Department of Medical Physiology, Division of Pathophysiology, University of Copenhagen, e Institute of Medical Anatomy, University of Copenhagen, Denmark

Keywords: Thick ascending limb, HenleDistal tubular functionProximal tubular functionLithiumSodiumDiabetic nephropathyGlomerulonephritisPolycystic kidney diseaseTubulointerstitial nephropathy

Related Articles for ""
Nephron 1998;79:167–172
https://doi.org/10.1159/000045020

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 27, 1998
Issue release date: June 1998

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Tamm-Horsfall protein (THP) and epidermal growth factor (EGF) are both synthesized by tubular cells in the distal part of the nephron and excreted with the urine. The present study examines the urinary excretion rates of the two peptides in relation to functional tubular markers in patients with chronic nephropathy. Four groups of patients with moderate to severely reduced renal function were studied: glomerulonephritis (n = 10), diabetic nephropathy (n = 11), tubulointerstitial nephropathy (n = 13), and polycystic kidney disease (n = 8). The renal function was evaluated by glomerular filtration rate (GFR) as an indicator for the general renal function, lithium clearance (CLi) as an indicator for proximal tubular function, and absolute distal reabsorption of sodium (ADRNa) as an indicator for distal tubular function. The excretion rate of EGF was rather closely correlated with GFR, CLi and ADRNa (Spearman coefficients of variation 0.88, 0.69, and 0.74, respectively). The correlations between the excretion rate of THP and GFR, CLi and ADRNa were weaker (Spearman coefficients of variation 0.68, 0.42, and 0.44). When the effect of GFR had been accounted for by multiple variance analyses, the excretion rates of the two peptides were still associated with ADRNa but not with CLi. In conclusion, the urinary excretion rates of especially EGF but also those of THP were correlated with renal function and distal tubular reabsorption of sodium in patients with chronic nephropathy.



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 27, 1998
Issue release date: June 1998

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

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1998, Vol.79, No. 2

June 1998

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