Neonatology
Original Paper
Surfactant Need by Gestation for Very Preterm Babies Initiated on Early Nasal CPAP: A Danish Observational Multicentre Study of 6,628 Infants Born 2000-2013Wiingreen R.a · Greisen G.b · Ebbesen F.c · Petersen J.P.d · Zachariassen G.e · Henriksen T.B.d · Mølholm Hansen B.aaDepartment of Paediatrics, Herlev Hospital, Herlev, bDepartment of Neonatology, Rigshospitalet, Copenhagen, cDepartment of Paediatrics, Aalborg University Hospital, Aalborg, dDepartment of Paediatrics, Aarhus University Hospital, Skejby, and eDepartment of Paediatrics, Odense University Hospital, Odense, Denmark
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Article / Publication Details
Received: March 24, 2016
Accepted: September 24, 2016
Published online: January 11, 2017
Issue release date: May 2017
Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Background: In recent years, early nasal continuous positive airway pressure (nCPAP) as respiratory support for preterm infants is being advocated as an alternative to prophylactic surfactant and treatment with mechanical ventilation. A number of infants treated with early nCPAP do not need treatment with surfactant, but few studies provide data on this. Since the 1990s, the first approach to respiratory support to preterm infants in Denmark has been early nCPAP combined with surfactant administration by the INSURE method by which the infant is intubated and surfactant administration is followed by rapid extubation to nCPAP if possible. Objectives: To investigate how often surfactant was administered in preterm infants with a gestational age below 34 weeks treated with early nCPAP as a first approach to respiratory support. Methods: An observational multicentre study including all inborn infants with a gestational age below 34 weeks admitted to 1 of the 4 level 3 neonatal intensive care units in Denmark in the period from 2000 to 2013. Results: A total of 6,628 infants were included in this study. We found that surfactant was administered in 1,056 of 1,799 (59%; 95% CI: 57-61%), in 821 of 2,864 (29%; 95% CI: 27-31%), and in 132 of 1,796 (7%; 95% CI: 6-8%) of the infants with a gestational age from 24 to 27, 28 to 31, and 32 to 33 weeks and 6 days, respectively. Conclusions: A large proportion of preterm infants treated with early nCPAP as the first approach to respiratory support was never treated with surfactant.
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Article / Publication Details
Received: March 24, 2016
Accepted: September 24, 2016
Published online: January 11, 2017
Issue release date: May 2017
Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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