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Original Paper

Anxiety and Coping Strategy Changes in Multiple Sclerosis Patients Initiating Fingolimod: The GRACE Prospective Study

Moreau T.a · Bungener C.b · Heinzlef O.c · Suchet L.d · Borgel F.e · Bourdeix I.f · Meite M.f · Rerat K.f · Chouette I.f · on behalf of the GRACE Study Group

Author affiliations

aDepartment of Neurology, CHU Dijon, Dijon, bInstitute of Psychology, Université Paris Descartes - Sorbonne Paris Cité, Paris, cDepartment of Neurology, CHI Poissy-St. Germain-en-Laye, Poissy, dDepartment of Neurology, CHU Marseille, Marseille, ePrivate Practice in Neurology, Grenoble, and fNovartis Pharma SAS, Rueil-Malmaison, France

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Eur Neurol 2017;77:47-55

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 09, 2016
Accepted: September 26, 2016
Published online: December 02, 2016
Issue release date: January 2017

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

The objective of this prospective study was to assess the changes in anxiety levels, and their relationship with coping strategies over the first four months of fingolimod treatment in patients with relapsing remitting multiple sclerosis (RRMS). Data were collected at the inclusion visit (Visit 1) and 4 months later (Visit 2). We used the Hospital Anxiety and Depression Scale (HADS) to assess the level of anxiety and the Coping Inventory for Stressful Situations scale to assess the coping strategies used when engaged with stressful situations. The HADS anxiety scores were compared between Visits 1 and 2, according to the preferred coping strategy. At Visit 1, half of the 198 patients included were considered to be anxious (doubtful or in a certain way). The same proportion preferentially used an avoidance-oriented strategy and one-third preferentially used an emotion-oriented strategy. The mean HADS anxiety score decreased significantly (p = 0.001) at Visit 2 (8.1 ± 4.0) compared to Visit 1 (8.8 ± 4.3), particularly in the group of patients who used an emotion-oriented strategy (p = 0.002). In conclusion, the initiation of fingolimod in patients with RRMS is followed by a decrease of anxiety levels which vary according to the coping strategy used.

© 2016 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 09, 2016
Accepted: September 26, 2016
Published online: December 02, 2016
Issue release date: January 2017

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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