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Original Paper

Prevalence and Renal Prognosis of Diagnosed Autosomal Dominant Polycystic Kidney Disease in Japan

Higashihara E.a · Nutahara K.a · Kojima M.b · Tamakoshi A.b · Yoshiyuki O.b · Sakai H.c · Kurokawa K.c

Author affiliations

a Department of Urology, Kyorin University School of Medicine, Tokyo, b Department of Preventive Medicine, Nagoya University School of Medicine, Nagoya, and c Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan

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Nephron 1998;80:421–427

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 07, 1998
Issue release date: December 1998

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

The prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease (ADPKD) in Japan were estimated. Hospital-based nationwide surveys were conducted in 1995. The number of ADPKD patients who visited hospitals but were not on chronic dialysis was estimated to be 10,000 (95% confidence interval: 8,200–11,900) and that of ADPKD patients on dialysis was 4,590, yielding a prevalence of ADPKD of 117 per million population at the end of 1994 (95% confidence interval: 102–132). The prevalence increased with age and reached a peak value of 261 per million population at the age group of 55–59 years. The rate of end-stage renal disease among living patients was calculated based on the assumption that the prevalence of ADPKD in the population under the age of 55 years was 261 per million population. The rate of end-stage renal disease increased with the progression of the patients’ age, reaching 49% at the age of 65–69 years and declining thereafter. Conclusion: The hospital-based prevalence of ADPKD is lower than the autopsy-based prevalence, suggesting that a fairly large number of these patients do not receive medical care in their lifetime. The probability of end-stage renal disease is at most 50% among ADPKD patients who visit a hospital.


References

  1. Gabow PA: Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332–342.
  2. Grantham JJ: Polycystic kidney disease: Neoplasia in disguise. Am J Kidney Dis 1990;15:110–116.
  3. Fick GM, Johnson AM, Hammond WS, Gabow PA: Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995;5:2048–2056.
  4. Gabow PA, Johnson AM, Kaehny WD, Kimberling WJ, Lezotte DC, Duley IT, Jones RH: Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease. Kidney Int 1992;41:1311–1319.
  5. The Japan Society for Transplantation: Registration of kidney transplantation in 1990. Jpn J Transplant 1991;26:494–517.
  6. Hashimoto S, Fukutomi K, Nagai M, Nakamura Y, Yanagawa H, Sasaki R, Ohno Y, Aoki K: Response bias in the nationwide epidemiological survey of an intractable disease in Japan. J Epidemiol 1991;1:27–30.
  7. Harris PC, Thomas S, MacCarthy AB, Stallings RL, Breuning MH, Jenne DE, Fink TM, Buckle VJ, Ratcliffe PJ, Ward CJ: A large duplicated area in the polycystic kidney disease 1 (PKD1) region of chromosome 16 is prone to rearrangement. Genomics 1994;23:321–330.
  8. Dalgaard OZ: Bilateral polycystic disease of the kidneys: A follow-up of two hundred and eighty-four patients and their families. Acta Med Scand 1957;158(suppl):13–255.
  9. Chan KW: Adult polycystic kidney disease in Hong Kong Chinese: An autopsy study. Pathology 1993;25:229–232.
  10. Zeier M, Geberth S, Ritz E, Jaeger T, Waldherr R: Adult polycystic kidney disease – Clinical problems. Nephron 1988;49:177–183.
    External Resources
  11. Iglesias CG, Torres VE, Offord KP, Holley KE, Beard CM, Kurland LK: Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935–1980. Am J Kidney Dis 1983;11:630–639.
  12. Davies F, Coles GA, Harper PS, Williams AJ, Evans C, Cochlin D: Polycystic kidney disease re-evaluated: A population-based study. Q J Med 1991;79:477–485.
  13. Ravine D, Walker RG, Gibson RN, Forrest SM, Richards RI, Friend K, Sheffield LJ, Kincaid-Smith P, Danks DM: Phenotype and genotype heterogeneity in autosomal dominant polycystic kidney disease. Lancet 1992;340:1330–1333.
  14. Milutinovic J, Fialkow PJ, Agodoa LY, Phillips LA, Rudd TG, Bryant JI: Autosomal dominant polycystic kidney disease: Symptoms and clinical findings. Q J Med 1984;53:511–522.
    External Resources
  15. Churchill DN, Bear JC, Morgan J, Payne RH, McManamon PJ, Gault MH: Prognosis of adult onset polycystic kidney disease re-evaluated. Kidney Int 1984;26:290–293.
  16. Gonzalo A, Rivera M, Quereda C, Ortuno J: Clinical features and prognosis of adult polycystic kidney disease. Am J Nephrol 1990;10:470–474.
  17. Mitcheson HD, Williams G, Castro JE: Clinical aspects of polycystic disease of the kidneys. Br Med J 1997;i:1196–1199.
  18. Higashihara E, Horie S: Genetic study of ADPKD in Japan. Kidney Int 1995;47:729.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 07, 1998
Issue release date: December 1998

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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