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Review

New Concepts of Cerebrospinal Fluid Physiology and Development of Hydrocephalus

Orešković D.a · Radoš M.b · Klarica M.b

Author affiliations

aDepartment of Molecular Biology, Ruđer Bošković Institute, and bDepartment of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 29, 2016
Accepted: September 21, 2016
Published online: December 21, 2016

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE

Abstract

The goal of this review is the presentation of the new (Bulat-Klarica-Orešković) hypothesis of cerebrospinal fluid (CSF) physiology and the ensuing new concept of hydrocephalus development in light of this hypothesis. The widely accepted classic hypothesis of CSF physiology and the traditional concept of hydrocephalus are contradicted by numerous experimental and clinical data, which consequently results in unsatisfying clinical treatment and patient recovery. Therefore, the newly presented concept of hydrocephalus development and possible future treatments are discussed. A new definition suggests that hydrocephalus is a pathological state in which CSF is excessively accumulated inside the cranial part of the CSF system, predominantly in one or more brain ventricles as a consequence of impaired hydrodynamics of intracranial fluids between CSF, brain, and blood compartments.

© 2016 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 29, 2016
Accepted: September 21, 2016
Published online: December 21, 2016

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE


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