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Original Paper

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Platt S.a · Al Zahrani Y.a · Singh N.b · Hill B.c · Cherian S.d · Singh A.D.a

Author affiliations

aDepartment of Ophthalmic Oncology, Cole Eye Institute, bCase Western Reserve University School of Medicine, cDepartment of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, and dDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA

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Ocul Oncol Pathol 2017;3:181-187

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 17, 2016
Accepted: November 15, 2016
Published online: February 02, 2017
Issue release date: September 2017

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 2296-4681 (Print)
eISSN: 2296-4657 (Online)

For additional information: https://www.karger.com/OOP

Abstract

Aim: The aim of this study was to report outcomes following radiation therapy in patients with biopsy-proven extranodal marginal zone lymphoma of the ocular adnexa and uvea. Methods: Records from a single institution were retrospectively reviewed from January 1997 to December 2015. The mean follow-up duration was 38 months (range 0-194). Radiation therapy was administered to 77 eyes (60 patients); 57 of the 77 eyes (74%) were treated with radiation only (range 20-36 Gy, median 15 fractions). Radiation cataract, radiation retinopathy, and optic neuropathy assessments were performed on all eyes treated with radiation. Results: 100% of the 47 patients treated with radiation therapy only had local control with an average dose of 26.5 Gy (median 25.2 [range 20-36] Gy; 150-200 cGy per fraction). Four patients lost 2 lines or more of vision after radiation. The most common complication of radiation therapy was cataract formation/progression in 19 eyes (25%). Radiation retinopathy was observed only in 1 patient (1%). Conclusion: Our results confirm that radiation therapy (median 25 Gy) for extranodal marginal zone lymphoma of the ocular adnexa is associated with high local control and low risk of visually significant complications.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 17, 2016
Accepted: November 15, 2016
Published online: February 02, 2017
Issue release date: September 2017

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 2296-4681 (Print)
eISSN: 2296-4657 (Online)

For additional information: https://www.karger.com/OOP


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