Nephron

Original Paper

Suppressive Effects of Perilla frutescens on Spontaneous IgA Nephropathy in ddY Mice

Makino T.a · Ono T.b · Muso E.b · Honda G.a · Sasayama S.b

Author affiliations

aDepartment of Pharmacognosy, Graduate School of Pharmaceutical Sciences, and bDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Keywords: Perilla frutescensLabiataeHerbal medicineddY miceIgA nephropathyNitric oxide

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Nephron 1999;83:40–46
https://doi.org/10.1159/000045471

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 31, 1999
Issue release date: September 1999

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Perilla frutescens (perilla) is a common herb used in Japan for garnishing raw seafood to protect the alimentary tract from inflammatory diseases. The present study was performed to investigate whether or not perilla prevents the development of lesions of IgA nephropathy in ddY mice which spontaneously develop this disease. After orally administering perilla extract to ddY mice from 8 to 42 weeks of age, the changes in urine, serum, and kidneys were evaluated. Perilla extract significantly suppressed proteinuria and glomerular IgA deposition (p < 0.01 and p < 0.05, respectively). The decreased serum IgA concentration in perilla-treated mice showed a significant correlation with glomerular IgA deposition. Such findings suggest that perilla reduced glomerular IgA deposition via suppression of IgA production in the serum. On the other hand, the nitric oxide concentration in the serum of perilla-treated mice was significantly higher than that observed in the controls. The addition of the sera of perilla-treated mice to quiescent cultured murine mesangial cells resulted in a cell proliferation which was less than in controls, suggesting that perilla might either directly prevent mesangial cell proliferation or prevent proliferation by regulating circulating cytokines. Such results indicate that perilla should prevent IgA nephropathy, thus representing a promising herbal medicine for glomerulonephritis.



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 31, 1999
Issue release date: September 1999

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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1999, Vol.83, No. 1

September 1999

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