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Original Paper

Salivary Testosterone during the Minipuberty of Infancy


Contreras M.a · Raisingani M.a · Chandler D.W.b · Curtin W.D.b · Barillas J.c · Brar P.C.a · Prasad K.a · Shah B.a · David R.a

Author affiliations

aDepartment of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA
bEndocrine Sciences Laboratory, LabCorp, Calabasas, CA, USA
cDepartment of Pediatrics, Woodhull Medical Center, Brooklyn, NY, USA

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Horm Res Paediatr

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2016
Accepted: November 01, 2016
Published online: January 10, 2017
Issue release date: March 2017

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: The hypothalamic-pituitary-gonadal axis is transiently activated during the postnatal months in boys, a phenomenon termed “minipuberty” of infancy, when serum testosterone (T) increases to pubertal levels. Despite high circulating T there are no signs of virilization. We hypothesize that free T as measured in saliva is low, which would explain the absence of virilization. Methods: We measured serum total T and free T in saliva using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 30 infant boys, aged 1–6 months, and in 12 adolescents, aged 11–17 years. Results: Total serum T in all infants was, as expected, high (172 ± 78 ng/dL) while salivary T was low (7.7 ± 4 pg/mL or 0.45 ± 0.20%). In contrast, salivary T in the adolescents was much higher (41 ± 18 pg/mL or 1.3 ± 0.36%) in relation to their total serum T (323 ± 117 ng/dL). We provide for the first time reference data for salivary T in infants. Conclusion: Measurement of salivary T by LC-MS/MS is a promising noninvasive technique to reflect free T in infants. The low free T explains the absence of virilization. The minipuberty of infancy is more likely of intragonadal than peripheral significance.


© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2016
Accepted: November 01, 2016
Published online: January 10, 2017
Issue release date: March 2017

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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