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Original Paper

Salivary Testosterone during the Minipuberty of Infancy


Contreras M.a · Raisingani M.a · Chandler D.W.b · Curtin W.D.b · Barillas J.c · Brar P.C.a · Prasad K.a · Shah B.a · David R.a

Author affiliations

aDepartment of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA
bEndocrine Sciences Laboratory, LabCorp, Calabasas, CA, USA
cDepartment of Pediatrics, Woodhull Medical Center, Brooklyn, NY, USA

Related Articles for ""

Horm Res Paediatr 2017;87:111-115

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2016
Accepted: November 01, 2016
Published online: January 10, 2017
Issue release date: March 2017

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

Background: The hypothalamic-pituitary-gonadal axis is transiently activated during the postnatal months in boys, a phenomenon termed “minipuberty” of infancy, when serum testosterone (T) increases to pubertal levels. Despite high circulating T there are no signs of virilization. We hypothesize that free T as measured in saliva is low, which would explain the absence of virilization. Methods: We measured serum total T and free T in saliva using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 30 infant boys, aged 1–6 months, and in 12 adolescents, aged 11–17 years. Results: Total serum T in all infants was, as expected, high (172 ± 78 ng/dL) while salivary T was low (7.7 ± 4 pg/mL or 0.45 ± 0.20%). In contrast, salivary T in the adolescents was much higher (41 ± 18 pg/mL or 1.3 ± 0.36%) in relation to their total serum T (323 ± 117 ng/dL). We provide for the first time reference data for salivary T in infants. Conclusion: Measurement of salivary T by LC-MS/MS is a promising noninvasive technique to reflect free T in infants. The low free T explains the absence of virilization. The minipuberty of infancy is more likely of intragonadal than peripheral significance.


© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2016
Accepted: November 01, 2016
Published online: January 10, 2017
Issue release date: March 2017

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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