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Original Paper

Free Access

The Effect of Intra-Dialytic Exercise on Inflammation and Blood Endotoxin Levels

Wong J.a, b · Davis P.a, b · Patidar A.b · Zhang Y.c · Vilar E.a, b · Finkelman M.c · Farrington K.a, b

Author affiliations

aLister Hospital, Stevenage, and bUniversity of Hertfordshire, Hertfordshire, UK; cAssociates of Cape Cod, Inc., Massachusetts, MA, USA

Corresponding Author

Jonathan Wong

Lister Hospital, Renal Research

Coreys Mill Lane, Stevenage

Hertfordshire SG1 4AB (UK)

E-Mail jonathan.wong@nhs.net

Related Articles for ""

Blood Purif 2017;44:51-59

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Abstract

Background: In healthy individuals, an acute inflammatory response occurs after intense exercise due to gut ischaemia and intestinal bacterial endotoxin translocation into the bloodstream. This process maybe exacerbated in patients who exercise during dialysis due to large volume shifts experienced by many during haemodialysis (HD). The acute effect of intra-dialytic exercise on blood endotoxins and inflammation is not known. Method: The effect of intra-dialytic exercise on blood endotoxin and inflammation was investigated in 10 patients and compared with resting haemodialysis. Blood was measured for endotoxin and inflammatory biomarkers before and after dialysis. Result: With the exception of one sample, all samples tested negative for endotoxin. Intra-dialytic exercise attenuated the rise of interleukin-6, tumour necrosis factor-α and high-sensitivity C-reactive protein after the HD procedure. Conclusion: Intra-dialytic exercise was not associated with an observable rise in blood endotoxin, although it may ameliorate the inflammatory effects of the HD procedure. Larger studies are needed to confirm this finding.

© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 15, 2016
Accepted: December 12, 2016
Published online: February 28, 2017
Issue release date: April 2017

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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