Nephron

Distinguished Scientists Lecture Series
Section Editors: Chan, J.C.M.; Krieg, R.J., Jr.; Scheinmann, J.I., Richmond, Va.

Obstructive Nephropathy: Lessons from Cystic Kidney Disease

Chevalier R.L.

Author affiliations

Department of Pediatrics, University of Virginia, School of Medicine, Charlottesville, Va., USA

Keywords: Obstructive nephropathyPolycystic kidney diseaseApoptosisEpidermal growth factorRenin-angiotensin system

Related Articles for ""
Nephron 2000;84:6–12
https://doi.org/10.1159/000045532

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Distinguished Scientists Lecture Series<br>Section Editors: Chan, J.C.M.; Krieg, R.J., Jr.; Scheinmann, J.I., Richmond, Va.

Published online: January 19, 2000
Issue release date: January 2000

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Obstructive nephropathy is one of the most important causes of renal failure in infants and children, while polycystic kidney disease (PKD) is a major cause of renal failure in the adult population. This review summarizes the evidence that there may be a number of mechanisms common to the pathophysiology of both conditions. In animal models of obstructive nephropathy and PKD, the renal tubular expression of epidermal growth factor is suppressed, and expression of clusterin is increased, both of which suggest arrested maturation or dedifferentiation of the tubular cell. There is a marked increase in apoptosis of epithelial cells in dilated tubules, associated with an increase in apoptotic stimuli. The renin-angiotensin system is activated in both obstructive nephropathy and PKD, which may contribute to tubular atrophy and interstitial fibrosis, which characterize the progression of both conditions. Focal cystic dilatation of the tubule is found in obstructive nephropathy, while tubular obstruction is present in cystic kidney disease. It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions.

© 2000 S. Karger AG, Basel



Related Articles:

References

  1. Warady BA: Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents. The 1995 Annual Report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 1997;11:49–64.
    External Resources
  2. Grantham JJ: The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: Recent advances. Am J Kidney Dis 1997;28:788–803.
    External Resources
  3. Chung KH, Chevalier RL: Arrested development of the neonatal kidney following chronic ureteral obstruction. J Urol 1996;155:1139–1144.
    External Resources
  4. Chevalier RL, Chung KH, Smith CD, Ficenec M, Gomez RA: Renal apoptosis and clusterin following ureteral obstruction: The role of maturation. J Urol 1996;156:1474–1479.
    External Resources
  5. Wolstenholme JT, Thornhill BA, Chevalier RL: Regulation of renal tubular cell proliferation and apoptosis by angiotensin II in the neonatal rat kidney with unilateral ureteral obstruction (abstract). Pediatr Res 1997;41:286.
  6. Yoo KH, Thornhill BA, Chevalier RL: Phenotypic transformation of renal tubular epithelial cells and interstitial fibroblasts following unilateral ureteral obstruction or single nephron obstruction (abstract). J Am Soc Nephrol 1996;7:1768.
  7. Yoo KH, Thornhill BA, Chevalier RL: Tubular epithelial cell epidermal growth factor receptor polarity is altered by unilateral ureteral obstruction (abstract). J Am Soc Nephrol 1996;7:1751.
  8. Orellana SA, Sweeney WE, Neff CD, Avner ED: Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 1995;47:490- 499.
    External Resources
  9. Harding MA, Chadwick LJ, Gattone VH II, Calvet JP: The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease. Dev Biol 1991;146:483- 490.
    External Resources
  10. Rosenberg ME, Manivel JC, Carone FA, Kanwar YS: Genesis of renal cysts is associated with clusterin expression in experimental cystic disease. J Am Soc Nephrol 1995;5:1669–1674.
    External Resources
  11. Kennedy WA II, Stenberg A, Lackgren G, Hensle TW, Sawczuk IS: Renal tubular apoptosis after partial ureteral obstruction. J Urol 1994;152:658–664.
    External Resources
  12. Winyard PJD, Nauta J, Lirenman DS, Hardman P, Sams VR, Risdon RA, Woolf AS: Deregulation of cell survival in cystic and dysplastic renal development. Kidney Int 1996;49:135–146.
    External Resources
  13. Gobe GC, Axelsen RA: Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Lab Invest 1987;56:273–281.
    External Resources
  14. Woo D: Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 1995;333:18–25.
    External Resources
  15. Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619–626.
    External Resources
  16. Lieberthal W, Levine JS: Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury. Am J Physiol 1996;271:F477-F488.
    External Resources
  17. Sawczuk IS, Hoke G, Olsson CA, Connor J, Buttyan R: Gene expression in response to acute unilateral ureteral obstruction. Kidney Int 1989;35:1315–1319.
    External Resources
  18. Cowley BD Jr, Smardo FL Jr, Grantham JJ, Calvet JP: Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc Natl Acad Sci USA 1998;84:8394–8398.
  19. Trudel M, D’Agati V, Costantini F: c-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int 1991;39:665–671.
    External Resources
  20. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994;124:1–6.
    External Resources
  21. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993;75:229–240.
    External Resources
  22. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR: Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol 1995;268:F73-F81.
    External Resources
  23. Chevalier RL, Smith CD, Krajewski S, Reed JC: Renal apoptosis following unilateral ureteral obstruction is associated with suppression of bcl-2 (abstract). J Am Soc Nephrol 1995;6:976.
  24. Chevalier RL: Chronic partial ureteral obstruction in the neonatal guinea pig. II. Pressure gradients affecting glomerular filtration rate. Pediatr Res 1984;18:1271–1277.
    External Resources
  25. Zucker B, Hanusch J, Bauer G: Glutathione depletion in fibroblasts is the basis for apoptosis induction by endogenous reactive oxygen species. Cell Death Differ 1997;4:388–395.
    External Resources
  26. Kayanoki Y, Fujii J, Islam KN, Suzuki K, Kawata S, Matsuzawa Y, Taniguchi N: The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species. J Biochem Tokyo 1996;119:817–822.
  27. Islam KN, Kayanoki Y, Kaneto H, Suzuki K, Asahi M, Fujii J, Taniguchi N: TGF-β1 triggers oxidative modifications and enhances apoptosis in hit cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radic Biol Med 1997;22:1007–1017.
    External Resources
  28. Modi KS, Morrissey J, Shah SV, Schreiner GF, Klahr S: Effects of probucol on renal function in rats with bilateral ureteral obstruction. Kidney Int 1990;38:843–850.
    External Resources
  29. Young MRA, Young IS, Johnston SR, Rowlands BJ: Lipid peroxidation assessment of free radical production following release of obstructive uropathy. J Urol 1996;156:1828–1832.
    External Resources
  30. Ricardo SD, Ding G, Eufemio M, Diamond JR: Antioxidant expression in experimental hydronephrosis: Role of mechanical stretch and growth factors. Am J Physiol 1997;272:F789-F798.
    External Resources
  31. Kinter M, Wolstenholme JT, Thornhill BA, Newton E, McCormick ML, Chevalier RL: Unilateral ureteral obstruction impairs renal antioxidant enzyme activation during sodium depletion. Kidney Int, in press.
  32. Maser RL, Calvet JP: Reduced expression of antioxidant and detoxicant enzyme genes in polycystic kidney disease (abstract). J Am Soc Nephrol 1996;7:1617.
  33. Torres VE, Bengal RJ, Litwiller RD, Wilson DM: Aggravation of polycystic kidney disease in Han:SPRD rats by buthionine sulfoximine. J Am Soc Nephrol 1997;8:1283–1291.
    External Resources
  34. Raaberg L, Nexo E, Mikkelsen JD, Poulsen SS: Immunohistochemical localization and developmental aspects of epidermal growth factor in the rat. Histochemistry 1988;89:351–356.
    External Resources
  35. Storch S, Saggi S, Megyesi J, Price PM, Safirstein R: Ureteral obstruction decreases renal prepro-epidermal growth factor and Tamm-Horsfall expression. Kidney Int 1992;42:89–94.
    External Resources
  36. Gattone VH, Andrews GK, Niu Fu-Wen, Chadwick LJ, Klein RM, Calvet JP: Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Dev Biol 1990;138:225–230.
    External Resources
  37. Gattone VH II, Lowden DA, Cowley BD Jr: Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice. Dev Biol 1995;169:504–510.
    External Resources
  38. Chevalier RL, Goyal S, Wolstenholme JT, Thornhill BA: Obstructive nephropathy in the neonate is attenuated by epidermal growth factor. Kidney Int 1998;54:38–47.
    External Resources
  39. Kennedy WA II, Buttyan R, Garcia-Montes E, D’Agati V, Olsson CA, Sawczuk IS: Epidermal growth factor suppresses renal tubular apoptosis following ureteral obstruction. Urology 1997;49:973–980.
    External Resources
  40. Gomez RA, Lynch KR, Sturgill BC, Elwood JP, Chevalier RL, Carey RM, Peach MJ: Distribution of renin mRNA and its protein in the developing kidney. Am J Physiol 1989;257:F850-F858.
    External Resources
  41. El-Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL: In situ localization of renin and its mRNA in neonatal ureteral obstruction. Am J Physiol 1990;258:F854-F862.
    External Resources
  42. Norwood VF, Carey RM, Geary KM, Jose PA, Gomez RA, Chevalier RL: Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Kidney Int 1994;45:1333–1339.
    External Resources
  43. El Dahr S, Gomez RA, Khare G, Peach MJ, Carey RM, Chevalier RL: Expression of renin and its mRNA in the adult rat kidney with chronic ureteral obstruction. Am J Kidney Dis 1990;15:575–582.
    External Resources
  44. Chevalier RL, Thornhill BA, Wolstenholme JT: Unique cellular responses of the developing kidney to unilateral ureteral obstruction: Role of angiotensin II (abstract). J Am Soc Nephrol 1997;8:388.
  45. Yoo KH, Norwood VF, El-Dahr SS, Yosipiv I, Chevalier RL: Regulation of angiotensin II AT1 and AT2 receptors in neonatal ureteral obstruction. Am J Physiol 1997;273:R503-R509
    External Resources
  46. Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int 1998;53:937–944.
    External Resources
  47. Graham PC, Lindop GBM: The anatomy of the renin-secreting cell in adult polycystic kidney disease. Kidney Int 1988;33:1084–1090.
    External Resources
  48. Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Wada T, Ishimura Y, Chatani F, Iwao H: Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury. Kidney Int 1994;46:1346–1358.
    External Resources
  49. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM: Renal injury from angiotensin II-mediated hypertension. Hypertension 1992;19:464–474.
    External Resources
  50. Ricardo SD, Levinson ME, DeJoseph MR, Diamond JR: Expression of adhesion molecules in rat renal cortex during experimental hydronephrosis. Kidney Int 1996;50:2002–2010.
    External Resources
  51. Chung KH, Gomez RA, Chevalier RL: Regulation of renal growth factors and clusterin by angiotensin AT1 receptors during neonatal ureteral obstruction. Am J Physiol 1995;268:F1117-F1123.
    External Resources
  52. Ishidoya S, Morrissey J, McCracken R, Klahr S: Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy. Kidney Int 1996;49:1110–1119.
    External Resources
  53. Fern R, Yesko CM, Thornhill BA, Kim HS, Smithies O, Chevalier RL: Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. J Clin Invest 1999, in press.
  54. Uemasu J, Nakaoka A, Kawasaki H, Ishikawa I, Yoshino Y, Shio H, Nemoto R, Nakamura I, Morio S: Association between angiotensin converting enzyme gene polymorphism and clinical features in autosomal dominant polycystic kidney disease. Life Sci 1997;60:2139–2144.
    External Resources
  55. Baboolal K, Ravine D, Daniels J, Williams N, Holmans P, Coles GA, Williams JD: Association of the angiotensin I converting enzyme gene deletion polymorphism with early onset of ESRF in PKD1 adult polycystic kidney disease. Kidney Int 1997;52:607–613.
    External Resources
  56. Fetterman GH, Ravitch MM, Sherman FE: Cystic changes in fetal kidneys following ureteral ligation: Studies by microdissection. Kidney Int 1974;5:111–121.
    External Resources
  57. Daikha-Dahmane F, Dommergues M, Muller F, Narcy F, Lacoste M, Beziau A, Dumez Y, Gubler MC: Development of human fetal kidney in obstructive uropathy: Correlations with ultrasonography and urine biochemistry. Kidney Int 1997;52:21–32.
    External Resources
  58. Tanner GA, Gretz N, Connors BA, Evan AP, Steinhausen M: Role of obstruction in autosomal dominant polycystic kidney disease in rats. Kidney Int 1996;50:873–886.
    External Resources
  59. Tanner GA, McQuillan PF, Maxwell MR, Keck JK, McAteer JA: An in vitro test of the cell stretch-proliferation hypothesis of renal cyst enlargement. J Am Soc Nephrol 1995;6:1230–1241.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Distinguished Scientists Lecture Series<br>Section Editors: Chan, J.C.M.; Krieg, R.J., Jr.; Scheinmann, J.I., Richmond, Va.

Published online: January 19, 2000
Issue release date: January 2000

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2000, Vol.84, No. 1

January 2000

Article

Recommend This
TOP