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Original Research Article

Comprehensive, Individualized, Person-Centered Management of Community-Residing Persons with Moderate-to-Severe Alzheimer Disease: A Randomized Controlled Trial

Reisberg B.a · Shao Y.b · Golomb J.a, c · Monteiro I.a · Torossian C.a · Boksay I.a · Shulman M.a, c · Heller S.a · Zhu Z.b · Atif A.a · Sidhu J.a · Vedvyas A.c · Kenowsky S.a

Author affiliations

aDepartment of Psychiatry, bDivision of Biostatistics, Department of Population Health and Environmental Medicine, and cDepartment of Neurology, New York University Langone Medical Center, New York, NY, USA

Related Articles for ""

Dement Geriatr Cogn Disord 2017;43:100-117

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: January 03, 2017
Published online: January 26, 2017
Issue release date: February 2017

Number of Print Pages: 18
Number of Figures: 10
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: The aim was to examine added benefits of a Comprehensive, Individualized, Person-Centered Management (CI-PCM) program to memantine treatment. Methods: This was a 28-week, clinician-blinded, randomized, controlled, parallel-group study, with a similar study population, similar eligibility criteria, and a similar design to the memantine pivotal trial of Reisberg et al. [N Engl J Med 2003;348:1333-1341]. Twenty eligible community-residing Alzheimer disease (AD) subject-caregiver dyads were randomized to the CI-PCM program (n = 10) or to usual community care (n = 10). Primary outcomes were the New York University Clinician's Interview-Based Impression of Change Plus Caregiver Input (NYU-CIBIC-Plus), assessed by one clinician set, and an activities of daily living inventory, assessed by a separate clinician set at baseline and at weeks 4, 12, and 28. Results: Primary outcomes showed significant benefits of the CI-PCM program at all post-baseline evaluations. Improvement on the NYU-CIBIC-Plus in the management group at 28 weeks was 2.9 points over the comparator group. The memantine 2003 trial showed an improvement of 0.3 points on this global measure in memantine-treated versus placebo-randomized subjects at 28 weeks. Hence, globally, the management program intervention benefits were 967% greater than memantine treatment alone. Conclusion: These results are approximately 10 times those usually observed with both nonpharmacological and pharmacological treatments and indicate substantial benefits with the management program for advanced AD persons.

© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: January 03, 2017
Published online: January 26, 2017
Issue release date: February 2017

Number of Print Pages: 18
Number of Figures: 10
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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