Intestinal Microbiome: Functional Aspects in Health and Disease

88th Nestlé Nutrition Institute Workshop, Playa del Carmen, September 2016

Editor(s): Isolauri, E. (Turku)
Sherman, P.M. (Toronto, ON)
Walker, W.A. (Charlestown, MA)

Human Milk Oligosaccharides

Compositional Analysis and Metabolism of Human Milk Oligosaccharides in Infants

Kunz C.a · Rudloff S.a, b

Author affiliations

aInstitute of Nutritional Sciences and bDepartment of Pediatrics, Justus Liebig University Giessen, Giessen, Germany

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Isolauri E, Sherman PM, Walker WA (eds): Intestinal Microbiome: Functional Aspects in Health and Disease. Nestlé Nutr Inst Workshop Ser. Nestec Ltd. Vevey/S. Karger AG Basel, © 2017, vol 88, pp 137-147
https://doi.org/10.1159/000455398

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Article / Publication Details

First-Page Preview
Abstract of Human Milk Oligosaccharides

Published online: March 27, 2017
Cover Date: 2017

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 1

ISBN: 978-3-318-06030-0 (Print)
eISBN: 978-3-318-06031-7 (Online)

Abstract

It is a great success that biotechnological means are available today to produce amounts of single human milk oligosaccharides (HMOs) in a purity which allows performing metabolic and functional studies even in humans. As recent data indicate that there is a link between the Lewis blood group and the secretor status of an individual and certain inflammatory diseases, this review will also focus on the metabolic fate of secretor- and Lewis blood group-specific components. We conclude that there is no simple urinary or fecal excretion pattern of HMOs, although the pattern in urine often reflects the mother's secretor/nonsecretor status. However, there are deviations for single HMOs which deserve special attention. In feces, the variation in excretion is much higher than in urine, which may be caused by variations in the infant's intestinal microbiota. A gradual decrease in HMO excretion with time as proposed earlier does not take place as even after 7 months of exclusive breastfeeding often intact HMOs can be detected in feces and urine. In addition, we found that whenever oligosaccharides were detected in feces, LNT, the major core structure of HMOs, was present. Hence, our data do not support speculations that LNT is a preferable source for the microbiota.

© 2017 Nestec Ltd., Vevey/S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Human Milk Oligosaccharides

Published online: March 27, 2017
Cover Date: 2017

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 1

ISBN: 978-3-318-06030-0 (Print)
eISBN: 978-3-318-06031-7 (Online)

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