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Original Paper

Temozolomide with or without Radiotherapy in Patients with Newly Diagnosed Glioblastoma Multiforme: A Meta-Analysis

Feng E.a · Sui C.b · Wang T.c · Sun G.c

Author affiliations

aDepartment of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, bDepartment of Neurology, Beihai Hospital, Yantai, and cDepartment of Neurosurgery, Yidu Central Hospital of Weifang, Weifang, China

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Eur Neurol 2017;77:201-210

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 22, 2016
Accepted: January 04, 2017
Published online: February 14, 2017
Issue release date: March 2017

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 5

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Background/Aim: The current meta-analysis evaluated the survival outcomes of newly diagnosed glioblastoma patients treated with radiotherapy (RT) alone and with RT + temozolomide (TMZ). Methods: Relevant studies were identified by an extensive literature search in Medline, Current Contents and Cochrane databases by 2 independent reviewers using the terms “glioblastoma multiforme/glioblastoma, TMZ, radiation therapy/RT and survival.” Results: Results revealed a median survival of 13.41-19 months in the combined treatment group, as opposed to 7.7-17.1 months in the RT-alone group. Progression-free survival (PFS) was also significantly different between the 2 groups (RT + TMZ, 6.3-13 months; RT-alone, 5-7.6 months). While there was no significant difference in the 6-month survival and 6-month PFS rates between the RT + TMZ and RT groups (pooled OR 0.690; p = 0.057 and OR 0.429, p = 0.052, respectively), the 1-year survival and 1-year PFS rates showed significant difference (OR 0.469; p = 0.030 and OR 0.245, p < 0.001, respectively). Conclusions: Concomitant RT + TMZ is more effective and improves the overall survival and PFS in patients with newly diagnosed glioblastoma.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 22, 2016
Accepted: January 04, 2017
Published online: February 14, 2017
Issue release date: March 2017

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 5

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE


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