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Novel Insights from Clinical Practice

Unusual Occurrence of Multifocal Desmoplastic Infantile Astrocytoma: A Case Report and Review of the Literature

Narayan V.a · Savardekar A.R.a · Mahadevan A.b · Arivazhagan A.a · Appaji L.c

Author affiliations

Departments of aNeurosurgery and bNeuro-Pathology, NIMHANS, and cDepartment of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, India

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Pediatr Neurosurg 2017;52:173-180

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: September 19, 2016
Accepted: January 08, 2017
Published online: February 22, 2017
Issue release date: June 2017

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

Abstract

Desmoplastic infantile gliomas are rare, benign tumors of the early infancy period. Two histological subtypes - desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma - have been described. The characteristic features of DIAs are lobar location, glial histology, and excellent prognosis after complete surgical excision. DIAs usually present as solitary, cortical-surfacing, solid-cystic neoplasms; however, atypical, aggressive, and multifocal variants of DIA have been reported in the literature. These rare DIAs presenting with multiple lesions pose a diagnostic as well as a therapeutic dilemma. We report an unusual case of an 8-month-old female infant diagnosed with multifocal (cranial and spinal) DIA and obstructive hydrocephalus and discuss the radiological and histological features of this rare variant of DIA. The patient underwent ventriculoperitoneal shunt placement to relieve the hydrocephalus, excisional biopsy from a surfacing lesion in the right frontal lobe, and multiple cycles of chemotherapy; however, the lesions continued to progress, and the patient is likely to have an unfavorable outcome.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: September 19, 2016
Accepted: January 08, 2017
Published online: February 22, 2017
Issue release date: June 2017

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE


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