Developmental Pharmacology and Therapeutics

 

Nonhomogeneous Redistribution of Mesenteric Blood Flow after Tolazoline during Group B Streptococcal Sepsis in Piglets

Meadow W.L. · Meus P.J.

Author affiliations

Department of Pediatrics, Wyler Children’s Hospital, University of Chicago, and Departments of Surgery and Cardiac Surgery, Michael Reese Hospital, Chicago, Ill., USA

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Dev Pharmacol Ther 1985;8:209–218

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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)

For additional information: https://www.karger.com/DPD

Abstract

The effect of tolazoline (Tz) on mesenteric blood flow was evaluated in a piglet model of group B streptococcal (GBS) sepsis. GBS infusion decreased cardiac output and mesenteric blood flow equivalently, while increasing systemic and mesenteric vascular resistance. At three doses between 2 and 25 mg/kg, Tz increased cardiac output and decreased systemic vascular resistance. However, at no dose did Tz improve the diminished mesenteric artery blood flow which accompanied GBS sepsis. The potential use of Tz in neonatal sepsis may be limited by its nonhomogeneous redistribution of blood flow.




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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)

For additional information: https://www.karger.com/DPD


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