Developmental Pharmacology and Therapeutics

 

Sex-Related Hyperthermic Response to Chlorpromazine in the Offspring of Rats Treated with Imipramine

Fujii T. · Ohtaki Y.

Author affiliations

Department of Pharmacology, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

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Dev Pharmacol Ther 1985;8:364–373

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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)

For additional information: https://www.karger.com/DPD

Abstract

The body temperature in male rats bom to mothers treated with saline or imipramine (5 mg/kg, IMI-F(1)) from day 1 to day 21 of gestation showed a significant decline between 8 and 13 weeks of age. The magnitude of the decline was greater in the IMI-Fi rats than in saline-F, rats. In contrast, the body temperature in the IMI-F, female rats showed a significant rise between 8 and 13 weeks of age. Adult IMI-F(1) male rats showed a significant hyperthermia for 1-2 h after an injection of chlorpromazine while the littermate female rats and the control male and female rats showed a marked hypothermia. The results suggest that prenatal exposure to imipramine induces sex-related alterations in the thermoregulatory centers.




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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)

For additional information: https://www.karger.com/DPD


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