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Original Paper

Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

Gómez-Gallego C.a · Kumar H.a · García-Mantrana I.d · du Toit E.e · Suomela J.-P.b · Linderborg K.M.b · Zhang Y.f · Isolauri E.c · Yang B.b · Salminen S.a · Collado M.C.d

Author affiliations

aFunctional Foods Forum, bFood Chemistry and Food Development, Department of Biochemistry, and cDepartment of Pediatrics, University of Turku, Turku, Finland; dInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Valencia, Spain; eMedical Microbiology, University of Cape Town, Cape Town, South Africa; fDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China

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Ann Nutr Metab 2017;70:184-190

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 16, 2016
Accepted: January 20, 2017
Published online: March 17, 2017
Issue release date: July 2017

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: The aim of the present study was to identify and quantify the polyamine levels in human milk obtained from different countries and through different modes of delivery, and to investigate their association with breast milk microbes. Methods: Mature breast milk samples were obtained from 78 healthy mothers after 1 month of lactation from 4 different geographical locations: Finland, Spain (Europe); South Africa (Africa); and China (Asia). Polyamines were determined using HPLC after dansyl derivatization and milk microbiota was obtained by 16S rRNA gene sequencing. Results: The mean values of polyamines in breast milk were 70.0, 424.2, and 610.0 nmol/dL for putrescine, spermidine and spermine, respectively, and 1,170.9 nmol/dL of total polyamines. The levels of putrescine were significantly higher in Spain (p < 0.05) and spermidine levels were significantly higher in Finland (p < 0.05) compared with other countries. Cesarean delivery had an impact on polyamine levels and it was related to an increase in the putrescine concentration being significant in Spanish samples (p < 0.01). Furthermore, putrescine levels were correlated positively with Gammaproteobacteria (r = 0.46, p < 0.001), especially with Pseudomonas fragi (r = 0.40, p < 0.001). Conclusions: The results demonstrate significant effect of geographical variations in human milk polyamine concentrations, being correlated with human milk microbiota composition. These differences may have an impact on infant development during lactation.

© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 16, 2016
Accepted: January 20, 2017
Published online: March 17, 2017
Issue release date: July 2017

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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