Developmental Pharmacology and Therapeutics
Impaired Oxidative Metabolism of Salicylate in Reye’s SyndromeMeert K.L. · Kauffman R.E. · Deshmukh D.R. · Sarnaik A.P.Department of Pediatrics, Children’s Hospital of Michigan Wayne State University School of Medicine,
Detroit, Mich., USA
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Article / Publication Details
Published online: August 11, 2017
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)
For additional information: https://www.karger.com/DPD
Abstract
Administration of salicylates during prodromal viral illness has been associated with the development of Reye’s Syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.
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Article / Publication Details
Published online: August 11, 2017
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0379-8305 (Print)
eISSN: 2504-2505 (Online)
For additional information: https://www.karger.com/DPD
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