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Original Paper

Haemodialysis and Cerebral Oedema

Walters R.J.L.a,b · Fox N.C.c · Crum W.R.c · Taube D.b · Thomas D.J.a

Author affiliations

Departments of aClinical Neurology and bRenal Medicine and Transplantation, St. Mary’s Hospital, London, and cDementia Research Group, The National Hospital for Neurology and Neurosurgery, London, UK

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Nephron 2001;87:143–147

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 16, 2001
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Background: Haemodialysis may cause neurological symptoms ranging from inconvenient feelings of disequilibrium to life-threatening neurological complications. There are animal data to suggest cerebral swelling may accompany haemodialysis and contribute symptomatically to dialysis disequilibrium. However, MR images acquired following haemodialysis often fail to demonstrate evidence of cerebral oedema. We wished to quantify any potential cerebral volume change which is caused by haemodialysis treatment. Method: Five renal patients and 5 control subjects had a two volumetric T1-weighted MRI scans on the same day. The patients were imaged immediately before and after haemodialysis. None were taking steroids. Precise positional matching (registration) was used to quantify cerebral volume change. Results: Patients had an increase in cerebral volume following dialysis which averaged 32.8 ml (SE 7.4 ml, 3% brain volume). The change in the controls was 1.4 ml (SE 0.6 ml), p < 0.001. No patient had significant neurological symptoms. Conclusion: Cerebral oedema developed in the patients following dialysis. There is a good biological model for these observations. Modifications to dialysis may help. Common problems which increase cerebral volume, e.g. acute stroke, require careful appraisal in these patients. These observations need consideration when quantifying atrophy in dialysis patients.

© 2001 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 16, 2001
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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