Complement

Original Paper

Protection against Complement-Mediated Cell Damage by Ca^2+ and Zn^2+

Micklem K.J.a · Alder G.M.b · Buckley C.D.b · Murphy J.c · Pasternak C.A.b

Author affiliations

(a) Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK; Departments of (b) Biochemistry and (c) Immunology, St George’s Hospital Medical School, Cranmer Terrace, London, UK

Related Articles for ""

Complement 1988;5:141–152

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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1988

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0253-5076 (Print)
eISSN: 2504-2424 (Online)

For additional information: https://www.karger.com/COD

Abstract

Ca^2+ and Zn^2+ prevent antibody-dependent complement-induced permeability changes in tonsil lymphocytes and Lettre cells. Lactate dehydrogenase leaks out from Lettre cells at high complementxell ratios, under which conditions higher concentrations of Ca2+ and Zn2+ are required for protection. Ca^2+ and Zn^2+ do not inhibit complement activation or C9 binding to Lettre cells, and prevent leakage through preformed lesions. It is concluded that the extent of complement-induced membrane damage depends on the concentration of extracellular Ca^2+, and may be modulated by changes in extracellular Ca^2+ or Zn^2+.




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Article / Publication Details

Published online: August 11, 2017
Issue release date: 1988

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0253-5076 (Print)
eISSN: 2504-2424 (Online)

For additional information: https://www.karger.com/COD


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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