Complement
Original Paper
Protection against Complement-Mediated Cell Damage by Ca^2+ and Zn^2+Micklem K.J.a · Alder G.M.b · Buckley C.D.b · Murphy J.c · Pasternak C.A.b(a) Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK; Departments of (b) Biochemistry and (c) Immunology, St George’s Hospital Medical School, Cranmer Terrace, London, UK
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Article / Publication Details
Published online: August 11, 2017
Issue release date: 1988
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 0253-5076 (Print)
eISSN: 2504-2424 (Online)
For additional information: https://www.karger.com/COD
Abstract
Ca^2+ and Zn^2+ prevent antibody-dependent complement-induced permeability changes in tonsil lymphocytes and Lettre cells. Lactate dehydrogenase leaks out from Lettre cells at high complementxell ratios, under which conditions higher concentrations of Ca2+ and Zn2+ are required for protection. Ca^2+ and Zn^2+ do not inhibit complement activation or C9 binding to Lettre cells, and prevent leakage through preformed lesions. It is concluded that the extent of complement-induced membrane damage depends on the concentration of extracellular Ca^2+, and may be modulated by changes in extracellular Ca^2+ or Zn^2+.
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Article / Publication Details
Published online: August 11, 2017
Issue release date: 1988
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 0253-5076 (Print)
eISSN: 2504-2424 (Online)
For additional information: https://www.karger.com/COD
Copyright / Drug Dosage / Disclaimer
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