Oncology Research and Treatment

Original Article

NORAD Expression Is Associated with Adverse Prognosis in Esophageal Squamous Cell Carcinoma

Wu X.a-c · Lim Z.-F.c · Li Z.d · Gu L.a,e · Ma W.a · Zhou Q.a · Su H.a · Wang X.a · Yang X.f · Zhang Z.a,g

Author affiliations

a State Key Laboratory of Oncology in South China & Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; b Department of Oncology, Guizhou Provincial People's Hospital, Guiyang, China; c WVU Cancer Institute, Mary Babb Randolph Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, U.S.A.; d Department of Oncology, Affiliated Hospital of Zunyi Medical College, Zunyi, China; e Puer University, Puer, China; f Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China; g Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Keywords: NORADSurvivalEsophageal squamous cell carcinomaLong non-coding RNAs

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Oncol Res Treat 2017;40:370-374
https://doi.org/10.1159/000464465

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: January 24, 2017
Accepted: February 24, 2017
Published online: May 10, 2017
Issue release date: June 2017

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT

Summary

Background: NORAD (non-coding RNA-activated by DNA damage) is a conserved, abundant, and broadly expressed long non-coding RNA, which functions to preserve genome stability. However, its prognostic significance in esophageal squamous cell carcinoma (ESCC) remains unclear. Material and Methods: The expression of NORAD was detected by quantitative real-time polymerase chain reaction in pairs of tumorous and adjacent normal tissues derived from 106 ESCC patients. We analyzed the potential relationship between NORAD expression levels in tumor tissues and clinicopathological features of ESCC patients and clinical outcome. Results: The relative expression levels of NORAD were significantly upregulated in tumor tissues (p < 0.001) compared to adjacent normal tissues. In addition, high expression of NORAD was correlated with larger tumor size (p = 0.021) and T stage (p = 0.045). Kaplan-Meier analysis indicated that patients with high NORAD expression had poor overall and disease-free survival (p < 0.001). Moreover, multivariate analysis showed that increased expression of NORAD was an independent predictor of overall survival (p = 0.001). Conclusion: Our data indicate that increased NORAD expression might serve as a novel molecular predictor of poor prognosis in ESCC patients and maybe a potential target for diagnosis and gene therapy.

© 2017 S. Karger GmbH, Freiburg



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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: January 24, 2017
Accepted: February 24, 2017
Published online: May 10, 2017
Issue release date: June 2017

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT

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2017, Vol.40, No. 6

June 2017

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The authors contributed equally to the manuscript.
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