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Clinical Study

Stereotactic Radiosurgery as Initial Surgical Management for Elderly Patients with Trigeminal Neuralgia

Cohen J.a · Mousavi S.H.b · Faraji A.H.b · Akpinar B.a · Monaco E.A.b · Flickinger J.C.c · Niranjan A.b · Lunsford L.D.a, b

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aUniversity of Pittsburgh School of Medicine, bDepartment of Neurological Surgery, and cDepartment of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

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Stereotact Funct Neurosurg 2017;95:158-165

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 21, 2016
Accepted: March 02, 2017
Published online: May 13, 2017
Issue release date: July 2017

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Background: Management of older patients with medically refractory trigeminal neuralgia (TN) is yet a matter of debate. Objective: We sought to determine the benefit of stereotactic radiosurgery (SRS) as the sole surgical management in older patients (≥70 years). Methods: One hundred and twenty-seven patients (≥70 years) with typical TN underwent SRS as initial surgical management. The median maximum dose for the first procedure was 80 Gy. Repeat SRS was performed in 46 patients who developed recurrent pain. Results: After the first SRS, the initial pain control was achieved in 91% of patients. Complete pain relief (Barrow Neurological Institute [BNI] score I) developed in 75 patients (59%) and was maintained in 59, 39, and 22% of patients at 1, 3, and 5 years. Following repeat SRS, the rate of complete pain relief was 79, 55, and 41% at 1, 3, and 5 years. The chance of BNI I preservation was greater after repeat SRS compared to initial SRS (hazards ratio: 2.02, p < 0.0001). The incidence of trigeminal sensory loss was 17% after initial SRS but increased to 39% after repeat SRS. Conclusions: SRS alone was used effectively in older TN patients to achieve pain control. Recurrent pain responded to retreatment but was associated with an increased risk of sensory dysfunction.

© 2017 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: July 21, 2016
Accepted: March 02, 2017
Published online: May 13, 2017
Issue release date: July 2017

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN


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