Neurosignals

Review

Localization, Physiological Significance and Possible Clinical Implication of Gastrointestinal Melatonin

Bubenik G.A.

Author affiliations

Department of Zoology, University of Guelph, Guelph, Ont., Canada

Keywords: MelatoninGastrointestinal tractLocalizationBinding sitesOntogenyPhylogenyPathologyMotilityFood intakeDigestionPineal glandMitosisHepatobiliary system

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Biol Signals Recept 2001;10:350–366
https://doi.org/10.1159/000046903

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: November 29, 2001
Issue release date: November – December

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: https://www.karger.com/NSG

Abstract

The gastrointestinal tract (GIT) is a major source of extrapineal melatonin. In some animals, tissue concentrations of melatonin in the GIT surpass blood levels by 10–100 times and the digestive tract contributes significantly to melatonin concentrations in the peripheral blood, particularly during the day. Some melatonin found in the GIT may originate from the pineal gland, as the organs of the digestive system contain binding sites, which in some species exhibit circadian variation. Unlike the production of pineal melatonin, which is under the photoperiodic control, release of GI melatonin seems to be related to periodicity of food intake. Melatonin and melatonin binding sites were localized in all GI tissues of mammalian and avian embryos. Postnatally, melatonin was localized in the GIT of newborn mice and rats. Phylogenetically, melatonin and melatonin binding sites were detected in GIT of numerous mammals, birds and lower vertebrates. Melatonin is probably produced in the serotonin-rich enterochromaffin cells (EC) of the GI mucosa and can be released into the portal vein postprandially. In addition, melatonin can act as an autocrine or a paracrine hormone affecting the function of GI epithelium, lymphatic tissues of the immune system and the smooth muscles of the digestive tube. Finally, melatonin may act as a luminal hormone, synchronizing the sequential digestive processes. Higher peripheral and tissue levels of melatonin were observed not only after food intake but also after a long-term food deprivation. Such melatonin release may have a direct effect on the various GI tissues but may also act indirectly via the CNS; such action might be mediated by sympathetic or parasympathetic nerves. Melatonin can protect GI mucosa from ulceration by its antioxidant action, stimulation of the immune system and by fostering microcirculation and epithelial regeneration. Melatonin may reduce the secretion of pepsin and the hydrochloric acid and influence the activity of the myoelectric complexes of the gut via its action in the CNS. Tissue or blood levels of melatonin may serve as a marker of GI lesions or tumors. Clinically, melatonin has a potential for a prevention or treatment of colorectal cancer, ulcerative colitis, irritable bowel syndrome, children colic and diarrhea.

© 2001 S. Karger AG, Basel



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References

  1. Zhdanova IV, Wurtman RJ, Lynch HJ, Yves JR, Dollins AB, Morabito C, Matheson JK, Schomer DL: Sleep-inducing effect of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552–558.
    External Resources
  2. Poeggeler B, Reiter RJ, Tan D-X, Chen L-D, Manchester LC: Melatonin, hydroxyl-radical-mediated oxidative damage, and aging: A hypothesis. J Pineal Res 1993;14:151–168.
    External Resources
  3. Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F: Melatonin: Peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;15:271–276.
  4. Reiter RJ: Melatonin: Lowering the high price of free radicals. News Physiol Sci 2000;15:246–250.
    External Resources
  5. Reiter RJ, Tan D-X, Cabrera J, D’Arpa D, Sainz RM, Mayo JC, Ramos S: The oxidant/antioxidant network: Role of melatonin. Biol Signal Recept 1999;8:56–63.
    External Resources
  6. Reiter RJ, Tan D-X, Qi W-B, Manchester LC, Karbownik M, Calvo RJ: Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 2000;9:160–171.
    External Resources
  7. Tan D-X, Manchester LC, Reiter Rj, Qi W-B, Karbownik M, Calvo JR: Significance of melatonin in antioxidative defense system: Reactions and products. Biol Signals Recept 2000;9:137–159.
    External Resources
  8. Huether G: The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 1993;49;665–670.
    External Resources
  9. Bubenik GA, Brown GM: Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of the rat. Biol Signals 1997;6:40–44.
    External Resources
  10. Raikhlin NT, Kvetnoy IM: Lightening effect of the extract of human appendix mucosa on frog skin melanophores. Bull Exp Biol Med 1974;8:114–116. (in Russian.)
  11. Lee PP, Hong GX, Pang SF: Melatonin in the gastrointestinal tract; in Fraschini F, Reiter RJ (eds): Role of melatonin and Pineal Peptides in Neuroimmunomodulation. New York, Plenum Press, 1991, pp 127–136.
  12. Chow PH, Lee PPN, Poon, AMS, Shiu SYW, Pang SF: The gastrointestinal system: A site of melatonin paracrine action; in Tang PL, Pang SF et al (eds): A universal photoperiod signals with diverse actions. Frontiers in Hormone Research. Basel, Karger, 1996, vol 21, pp 123–132.
  13. Martin MT, Azpiroz F, Malagelada JR: Melatonin and the gastrointestinal system. Therapie 1998;53:453–458.
    External Resources
  14. Bubenik GA, Blask DE, Brown GM, Maestroni GJM, Pang SF, Reiter RJ, Viswanathan M, Zisapel N: Prospects of clinical utilization of melatonin. Biol Signals Recept 1998;7:195–219.
    External Resources
  15. Bubenik GA: Localization and physiological significance of gastrointestinal melatonin; in R Watson (ed): Melatonin in Health Promotion. Boca Raton, CRC Books, 1999 pp 21–39.
  16. Kachi T, Kurushima M: Review. Pineal-digestive organ relations: Physiological and pathophysiological significance of melatonin in the digestive system. Hirosaki Med J 2000;51:93–108.
  17. Reiter RJ: Pineal melatonin: Cell biology of its synthesis and its physiological interactions. Endocrinol Rev 1991;12:151–180.
    External Resources
  18. Lerner AB, Case JD, Lee TH, Mori W: Isolation of melatonin, the pineal factor that lightens melanocytes. J Am Chem Soc 1958;80:2587.
  19. Wurtman RJ, Axelrod J, Phillips LS: Melatonin synthesis in the pineal gland: Control by light. Science 1963;142:1071–1073.
  20. Cardinali DP, Rosner JM: Metabolism of serotonin by the rat retina in vitro. J Neurochem 1971;18:1769–1770.
    External Resources
  21. Bubenik GA, Brown GM, Uhlir I, Grota LJ: Immunohistological localization of N-acetylindolealkylamines in the pineal gland, retina and cerebellum. Brain Res 1974;81:233–242.
    External Resources
  22. Bubenik GA, Brown GM, Grota LJ: Differential localization of N-acetylated indolealkylamines in CNS and the Harderian gland using immunohistology. Brain Res 1976a;118:417–427.
  23. Bubenik GA, Purtill RA, Brown GM, Grota LJ: Melatonin in the retina and the Harderian gland. Ontogeny, diurnal variations and melatonin treatment. Exp Eye Res 1978;27:323–333.
    External Resources
  24. Pang SF, Allen AE: Extra-pineal melatonin in the retina: Its regulation and physiological function. Pineal Res Rev 1986;4:55–95.
  25. Bubenik GA, Brown GM, Grota LJ: Immunohistological localization of melatonin in the rat Harderian gland. J Histochem Cytochem 1976;24:1173–1177.
    External Resources
  26. Reiter RJ, Richardson BA, Hurlbut EC: Pineal, retinal and Harderian gland melatonin in a diurnal species, the Richardson’s ground squirrel (Spermophilus richardsonii). Neurosci Lett 1981;22:285–288.
    External Resources
  27. Bubenik GA: Immunohistological localization of melatonin in the salivary glands of the rat. Adv Biosci 1980;29:95–112.
  28. Cardinali DP, Wurtman RJ: Hydroxyindole-O-methyl transferase in rat pineal, retina and Harderian gland. Endocrinology 1972;91:247–252.
    External Resources
  29. Ralph CL: Melatonin production by extra-pineal tissues. Adv Biosci 1980;29:35–46.
  30. Kvetnoy IM, Raikhlin NT, Tolkachev VN: Chromatographical detection of melatonin (5-methoxy-N-acetylserotonin) and its biological precursors in enterochromaffine cells. Doklady Acad Nauk SSSR 1975;221:226–227. (in Russian.)
  31. Raikhlin NT, Kvetnoy IM: Melatonin and enterochromaffine cells. Acta Histochem 1976;55:19–25.
    External Resources
  32. Rakhlin NT, Kvetnoy IM, Tolkachev VN: Melatonin may be synthesized in enterochromafinne cells. Nature 1975;255:344–345.
    External Resources
  33. Raikhlin NT, Kvetnoy IM, Kadagidze ZG, Sokolov AV: Immunomorphological studies on synthesis of melatonin in enterochromaffine cells. Acta Histochem Cytochem 1978;11:75–77.
  34. Kvetnoy IM: Extrapineal melatonin: Location and role within diffuse neuroendocrine system. Histochem J 1999;31:1–12.
    External Resources
  35. Bubenik GA, Brown GM, Grota LJ: Immunohistological localization of melatonin in the rat digestive tract. Experientia 1977;33:662–663.
    External Resources
  36. Espamer V, Asero B: Identification of enteramine the specific hormone of enterochromaffin cell system, as 5-hydroxytryptamine. Nature 1952;169:800–801.
  37. Holloway WR, Grota LJ, Brown GM: Determination of immunoreactive melatonin in the colon of rat by immunocytochemistry. J Histochem Cytochem 1980;28:255–262.
    External Resources
  38. Vakkuri O, Rintamaki H, Leppaluoto J: Presence of immunoreactive melatonin in different tissues of the pigeon. Gen Comp Endocrinol 1985a;58:69–75.
  39. Huether G, Poegeller B, Reimer R, George A: Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci 1992;51:945–953.
    External Resources
  40. Poeggeler B: Vergleichende Untersuchungen ueber Melatonin und strukturverwandte Tryptophanmetabolite. (Comparative studies on melatonin and structurally-related tryptophan metabolites.) PhD Thesis, University of Göttingen, 1992 (in German).
  41. Bubenik GA, Pang SF, Hacker RR, Smith PS: Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food. J Pineal Res 1996;21:251–256.
    External Resources
  42. Bubenik GA, Hacker RR, Brown GM, Bartos L: Melatonin concentrations in the luminal fluid, mucosa and muscularis of the bovine and porcine gastrointestinal tract. J Pineal Res 1999;29:56–63.
  43. Vician M, Zeman M, Herichova I, Blazicek P, Matis P: Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery. J Pineal Res 1999;27:64–169.
  44. Bubenik GA, Pang SF: The role of serotonin and melatonin in the gastrointestinal physiology: Ontogeny, regulation of food intake and mutual 5-HT, melatonin feedbacks. J Pineal Res 1994;16:91–99.
    External Resources
  45. Bubenik GA, Pang SF: Melatonin levels in the gastrointestinal tissue of fish, amphibians and a reptile. Gen Comp Endocrinol 1997;106:415–419.
    External Resources
  46. Thomas L, Drew JE, Abramovich DR, Williams LM: The role of melatonin in the human fetus (Review). Int J Mol Med 1998;1:539–543.
    External Resources
  47. Williams LM, Hannah LT, Adam CL, Bourke DA: Melatonin receptors in red deer fetuses (Cervus elaphus). J Reprod Fertil 1997;110:145–151.
    External Resources
  48. Bubenik GA, Brown GM, Hacker RR, Bartos L: Melatonin concentration in the gastrointestinal tissues of bovine fetuses. Acta Vet Brno 2000;69:177–182.
  49. Bubenik GA: Localization of melatonin in the digestive tract of the rat. Effect of maturation, diurnal variation, melatonin treatment and pinealectomy. Horm Res 1980;12:313–323.
    External Resources
  50. Illnerova H: The effect of light in the development of hydroxyindole-O-methyltransferase activity in the rat pineal gland. Acta Nervosa Sup Prague 1972;14:130–131.
  51. Illnerova H: Melatonin rhythm in the human milk. J Clin Endocr Metab 1993;77:838–841.
    External Resources
  52. Lee PP, Pang SF: Melatonin and its receptors in the gastrointestinal tract. Biol Signals 1993;2:181–193.
    External Resources
  53. Herichova I, Zeman M: Perinatal development of melatonin production in gastrointestinal tract of domestic chicken; in Toenhardt H, Lewin R (eds): Investigations of perinatal development of birds. Berlin, Free Univ, 1996, pp 109–116.
  54. Messner M, Huether G, Lorf T, Ramdori G, Schwoerrer H: Presence of melatonin in the human hepatobiliary tract. Life Sci 2001;69:543–551.
    External Resources
  55. Kopin IJ, Pare CMB, Axelrod J, Weissbach H: The fate of melatonin in animals. J Biol Chem 1961;236:3072–3075.
  56. DeBoer H: The influence of photoperiod and melatonin on hormone levels and operand light demand in the pig. PhD Thesis, University of Guelph, 1988.
  57. Bubenik GA, Ayles HL, Ball RO, Friendship RM, Brown GM: Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs. J Pineal Res 1998;24:62–66.
    External Resources
  58. Vakkuri O, Rintamaki H, Leppaluoto J: Plasma and tissue concentrations of melatonin after midnight light exposure and pinealectomy in the pigeon. J Endocrinol 1985;105:263–268.
    External Resources
  59. Huether G: Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin. Ann NY Acad Sci 1994;719:146–158.
    External Resources
  60. Herichova I, Zeman M: Rhythmic changes of melatonin in the circulation and tissues of broiler chickens. Vet Med-Czech 1999;44:263–267.
  61. Kennaway DJ, Firth RJ, Philipou G, Matthews CD, Seamark RF: A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry. Endocrinology 1977;101:119–127.
    External Resources
  62. Huether G, Messner M, Rodenback A, Hardeland R: Effects of continuous infusion on steady state plasma melatonin levels under near physiological conditions. J Pineal Res 1998;24:146–151.
    External Resources
  63. Messner M, Hardeland R, Rodenbeck A, Huether G: Tissue retention and subcellular distribution of continuously infused melatonin in rats under near physiological conditions. J Pineal Res 1998;25:251–259.
    External Resources
  64. Bubenik GA, Niles LO, Pang SF, Pentney PJ: Diurnal variations and binding characteristics of melatonin in the mouse brain and gastrointestinal tissues. Comp Biochem Physiol 1993;104A:377–380.
  65. Pontoire C, Bernard M, Silvain C, Collin J-P, Voissin P: Characterization of melatonin binding sites in chicken and human intestines. Eur J Pharmacol 1993;247:111–118.
    External Resources
  66. Lee PPN, Shiu SYU, Chow PH, Pang SF: Regional and diurnal studies on melatonin binding sites in the duck gastrointestinal tract. Biol Signals 1995;4:212–224.
    External Resources
  67. Poon AMS, Mak ASY, Luk HT: Melatonin and 2[125I]iodomelatonin binding sites in the human colon. Endocrine Res 1996;22:77–94.
    External Resources
  68. Poon AMS, Chow PH, Mak ASY, Pang SF: Autoradiographic localization of 2[125I]iodomelatonin binding sites in the gastrointestinal tract of mammals including humans and birds. J Pineal Res 1997;23:5–14.
    External Resources
  69. Bogoeva M, Mileva M, Aljakov M: Regional and diurnal variations of 3H-melatonin binding sites in mouse alimentary tract. CR Acad Bulgare Sci 1994;12:107–109.
  70. Bubenik GA, Ball RO, Pang SF: The effect of food deprivation on brain and gastrointestinal tissue levels of tryptophan, serotonin, 5-hydroxyindoleacetic acid, and melatonin. J Pineal Res 1992;12:7–16.
    External Resources
  71. Bubenik GA, Pang SF, Cockshut JR, Smith PS, Grovum LW, Friendship RM, Hacker RR: Circadian variation of portal, arterial and venous blood levels of melatonin in pigs and its relationship to food intake and sleep. J Pineal Res 2000;28:9–15.
    External Resources
  72. Menendez-Pelaez A, Poeggeler B, Reiter RJ, Barlow-Walden L, Pablos MI, Tan D-X: Nuclear localization of melatonin in the different mammalian tissues: Immunocytochemical and radioimmunoassay evidence. J Cell Biol 1993;53:373–382.
  73. Quay WB, Ma YH: Demonstration of gastrointestinal hydroxyindole-O-methyl transferase. IRCS Med Sci 1976;4:563.
  74. Hong GX, Pang SF: N-acetyltransferase activity in the quail (Coturnix coturnix jap) duodenum. Comp Biochem Physiol 1995;112B:251–255.
  75. Hintermann E, Grieder NC, Amherd R, Brodbeck D, Meyer UA: Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melatogaster expressed in the nervous system and the gut. Proc Natl Acad Sci USA 1996;93:12315–12320.
    External Resources
  76. Vaughan GM, Reiter RJ: Pineal dependence of the Syrian hamster’s nocturnal serum melatonin surge. J Pineal Res 1986;3:9–14.
    External Resources
  77. Yaga H, Reiter RJ, Richardson BA: Tryptophan loading increases day time serum melatonin in intact and pinealectomized rats. Life Sci 1993;52:1231–1238.
    External Resources
  78. Kezuka H, Iigo I, Furukawa K, Aida K, Hanyu I: Effects of photoperiod, pinealectomy and ophtalmectomy on circulating melatonin rhythms in the Goldfish (Carassius auratus). Zool Sci 1992;9:1147–1153.
  79. Huether G, Hajak G, Reimer A, Poeggeler B, Bloomer M, Rodenback A, Ruuther E: The metabolic fate of infused L-tryptophan in men: Possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites. Psychopharmacology 1992;106:422–432.
  80. Brzozowski T, Konturek PCh, Konturek SG, Pajdo R, Bielanski W, Brzozowska I, Stachura J, Hahn EG: The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia and aspirin. J Pineal Res 1997;23:79–89.
    External Resources
  81. Ozaki Y, Lynch HJ: Presence of melatonin in plasma and urine of pinealectomized rats. Endocrinology 1976;99:641–644.
    External Resources
  82. Steindl PE, Finn B, Bendok B, Rothke S, Zee PC, Blei AT: Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. Ann Intern Med 1995;123:274–277.
    External Resources
  83. Steindl PE, Ferenci P, Marktl W: Impaired hepatic catabolism of melatonin in cirrhosis. Ann Intern Med 1997;127:494.
  84. Herichova I, Zeman M, Veselovsky J: Effect of tryptophan administration on melatonin concentrations in the pineal gland, plasma and gastrointestinal tract of chickens. Acta Vet Brno 1998;67:89–95.
  85. Dubbels R, Reiter RJ, Klenke E, Goebel A, Schankenberg E, Ehlers C, Schiwara HW, Schoot W: Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J Pineal Res 1995;18:28–31.
    External Resources
  86. Hattori A, Migitaka H, Iigo M , Itoh M, Yamamoto K, Ohtaneki-Kaneko R, Tara M, Suzuki T, Reiter RJ: Identification of melatonin in plants and its effect on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochem Mol Biol Ont 1995;35:627–634.
  87. Tan D-X, Manchester LC, Reiter RJ, Qi W, Hanes M, Farley NJ: High physiological levels of melatonin in the bile of mammals. Life Sci 1999;65:2523–2529.
    External Resources
  88. Barajas-Lopez C, Peres AL, Espinosa-Luna R, Reyes-Vazquez C, Prieto-Gomez B: Melatonin modulates cholinergic transmission by blocking nicotinic channels in the guinea-pig submucous plexus. Eur J Pharmacol 1996;312:319–325.
    External Resources
  89. Legris GJ, Will PC, Hopfer U: Inhibition of amiloride-sensitive sodium conductance by indoleamines. Proc Natl Acad Sci USA 1982;79:2040–2050.
  90. Chan HC, Lui KM, Wong WS, Poon AMS: Effect of melatonin on chloride secretion by human colonic T84 cells. Life Sci 1998;23:2151–2158.
    External Resources
  91. Dubocovich ML, Cardinali DP, Guardiola-Lemaitre B, Hagan RM, Krause DN, Sugden D, Yocca FD et al: Melatonin receptors. The IUPHAR Receptor Compendium, 1998, pp 187–193.
  92. Rice J, Mayor J, Tucker HA, Bielski RJ: Effect of light therapy on salivary melatonin in seasonal affective disorder. Psychiatry Res 1995;56:221–226.
    External Resources
  93. Aldhous M, Franey C, Wright J, Arend J: Plasma preparations of melatonin in man following oral absorption of different preparations. Br J Pharmac 1985;19:517–521.
  94. Krieger DT, Hauser H, Krey LC: Suprachiasmatic nucleus lesions do not abolish food-shifted circadian rhythmicity and temperature rhythmicity. Science 1977;197:398–402.
    External Resources
  95. Zafar NP, Morgan E: Feeding entrains an endogenous rhythm of swimming activity in the blind Mexican cave fish. Proc 8th Meeting of Eur Soc Chronobiol 1992, pp 165–166.
  96. Roky R, Kapas L, Taishi P, Fang J, Krueger JM: Food distribution alters the diurnal distribution of sleep in rats. Physiol Behav 1999;67:697–703.
    External Resources
  97. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH: Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci 1995;91:1824–1828.
  98. Dawson D, Gibbon S, Singh P: The hypothermic effect of melatonin on core body temperature: Is more better? J Pineal Res 1996;20:192–197.
    External Resources
  99. Cagnaci A, Soldani R, Yen SSC: The effect of light on core body temperature is mediated by melatonin in women. J Clin Endocrinol Metab 1993;76:1036–1038.
    External Resources
  100. Quastel R, Rahamimoff R: Effect of melatonin on spontaneous contraction and response to 5-hydroxytryptramine of rat isolated duodenum. Br J Pharmacol 1965;24:455–461.
  101. Fioretti MC, Menconi E, Ricardi C: Mechanism of the in vitro 5-hydroxytryptamine (5-HT) antagonism exerted by pineal indole derivatives. Riv Farmacol Ter 1974;5:43–49.
  102. Fioretti MC, Menconi E, Ricardi C: Study on the type of antiserotonergic antagonism exerted in vitro on rat’s stomach by pineal indole derivatives. Il Farmaco [Ed Prat] 1974;29:4101–412. (in Italian.)
  103. Bubenik GA: The effect of serotonin, N-acetylserotonin, and melatonin on spontaneous contraction of isolated rat intestine. J Pineal Res 1986;3:41–54.
    External Resources
  104. Harlow HJ, Weekly BL: Effect of melatonin on the force of spontaneous contractions of in vitro rat small and large intestine. J Pineal Res 1986;3:277–284.
    External Resources
  105. Bubenik GA, Dhanvantari S: Influence of serotonin and melatonin on some parameters of gastrointestinal activity. J Pineal Res 1989;7:333–344.
    External Resources
  106. Bubenik GA, Dhanwantari S: The effect of serotonin and melatonin on the digestive processes of the mouse. Adv Pineal Res 1989;3:2437–252.
  107. Chik C, Ho AK, Brown GM: Effect of food restriction on 24-h serum and pineal melatonin content in male rats. Acta Endocrinol 1987;115:507–513.
    External Resources
  108. Pierpaoli W, Dall’Ara A, Pedrino E, Regelson W: The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Ann NY Acad Sci 1991;621:291–313.
    External Resources
  109. Huether G: Melatonin as an antiaging drug: Between facts and fantasy. Gerontology 1996;42:87–96.
    External Resources
  110. Trentini GP, De Gaetani AR, Criscuolo M: Pineal gland and aging. Aging 1991;3:103–106.
  111. Anisimov VN, Bondarenko LA, Khavinson KM: Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin levels in old rats. Ann NY Acad Sci 1992;673:53–57.
    External Resources
  112. Quay WB: Pineal Chemistry. Springfield, Thomas, 1994, pp 137–200.
  113. Partridge WM, Mietus LJ: Transport of albumin-bound melatonin through the blood-brain barrier. J Neurochem 1980;34:1761–1763.
    External Resources
  114. Kopin IJ, Pare CMB, Axelrod J, Weissbach H: 6-Hydroxylation, the major metabolic pathway for melatonin. Biochem Biophys Acta 1960;40:370–377.
  115. Zee PC, Mehta R, Turek FW, Blei A T: Portocaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in rats. Brain Res 1991;560:17–22.
    External Resources
  116. Cordoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei A: High prevalence of sleep disturbance in cirrhosis. Hepatology 1998;27:339–345.
    External Resources
  117. Hertz-Eshel M, Rahamimoff R: Effect of melatonin on uterine contractility. Life Sci 1965;4:1367–1372.
    External Resources
  118. Viswanathan M, Laitinen JT, Saavendra JM: Expression of melatonin receptors in arteries involved in the thermoregulation. Proc Natl Acad Sci USA 1990;87:6200–6203.
    External Resources
  119. Viswanathan M, Scalberg E, Delagrange P, Guardiola-Lamaitre B, Saavendra JM: Melatonin receptors mediate contraction of rat cerebral artery. NeuroReport 1997;8:3847–3849.
    External Resources
  120. Reyes-Vasquez C, Naranjo-Rodriguez EB, Garcia-Segoviano JA, Trujillo-Santana J, Prieto-Gomez B: Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscles. J Pineal Res 1997;22:1–8.
    External Resources
  121. Storr M, Schudziarra V, Allescher H-D: Inhibition of small conductance K+channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus. Can J Pharmacol Physiol 200;78:799–806.
  122. Kravtsov GM, Poon AMS, Pang SF: An antiadrenergic effect of melatonin on quail caecal smooth muscle: Relationship between protein kinase A and tyrosine kinase. Biol Signals Recept 1999;8:203–204.
  123. Benouali-Pellissier S: Melatonin is involved in cholecystokinin-induced changes of ileal motility in rats. J Pineal Res 1994;17:79–85.
    External Resources
  124. Kachi T, Suzuki T, Yanagisawa M, Kimura N, Irie T: Pineal-gut relations. Hirosaki Med J 1999;51(suppl) S209-S213.
  125. Lucchelli A, Santagostino-Barbone MG, Tonini M: Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: The role of 5-HT4 and melatonin receptors. Br J Pharmacol 1997;121:1775–1781.
    External Resources
  126. Merle A, Delagrange Ph, Renard P, Lesieur D, Cuber JC, Roche M, Pellessier S: Effect of melatonin on motility pattren of small intestine in rats and its inhibition by melatonin receptor antagonist S 221152. J Pineal Res 2000;29:116–124.
    External Resources
  127. Bogoeva MV, Mileva MS, Tsanova KS, Gabev EE: Study on the circadian rhythm of duodenum mitotic activity after a single melatonin treatment of mice at the points of dark-light and light-dark transition. CR Acad Bulgare Sci 1998;51:12–16.
  128. Bogoeva MV, Mileva MS, Gabev EE: Changes of the circadian rhythm of colonic mitotic activity after single melatonin application. CR Acad Bulgare Sci 1998;51: 6–8.
  129. Bindoni M: Relationship between the pineal gland and the mitotic activity of some tissues. Arch Sci Biol 1971;55:3–21.
  130. Callaghan BD: The effect of pinealectomy and autonomic denervation on crypt cell proliferation in the rat small intestine. J Pineal Res 1991;10:180–185.
    External Resources
  131. Callaghan BD: The long-term effect of pinealectomy on the crypts of the rat gastrointestinal tract. J Pineal Res 1995;18:191–196.
    External Resources
  132. Wajs E, Lewinski A: Melatonin and N-acetylserotonin – two pineal indoles inhibiting the proliferation of jejunal epithelial cells in rats. Med Sci Res 1988;16:1125–227.
  133. Lewinski A, Rybicka I, Wajs M, Szkundlinski M, Pawlikowski M: Influence of pineal indoleamines on the mitotic activity of gastric mucosa epithelial cells in the rat: Interaction with omeprazole. J Pineal Res 1991;10:104–108.
    External Resources
  134. Pawlikowski M: The pineal gland and cell proliferation. Adv Pineal Res 1986;1:27–30.
  135. Bogoeva M, Mileva MS, Tsanova KS: Effect of exogenous melatonin on the twenty-four-hour mitotic activity of some normal mouse tissues. CR Acad Bulgare Sci 1993;46:107–110.
  136. Pentney P, Bubenik GA: Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res 1995;19:31–39.
    External Resources
  137. Zerek-Melen G, Lewinski A, Kulak J: The opposing effect of high and low doses of melatonin upon mitotic activity of the mouse intestinal epithelium. Endokrynol Pol 1987;38:317–323.
    External Resources
  138. Cho CH, Pang SF, Chen BW, Pfeiffer CJ: Modulating action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomach. J Pineal Res 1989;6:89–97.
    External Resources
  139. Khan R, Daya S, Potgieter B: Evidence for the modulation of the stress response by the pineal gland. Experientia 1990;46:860–862.
    External Resources
  140. Melchiorri DE, Sewerynek E, Reiter RJ, Ortiz GG, Poegeller B, Nistico G: Suppresive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo. Br J Pharmacol 1997;121:264–270.
    External Resources
  141. Ayles HL, Ball RO, Friendship RM, Bubenik GA: The effect of graded levels of melatonin on growth performance and gastric ulcers in pigs. Can J Anim Sci 1996;179:79–85.
  142. De La Lastra CA, Cabeza J, Motilva V, Martin MJ: Melatonin protects against gastric ischemia-reperfusion injury in rats. J. Pineal Res 1997;23:47–52.
  143. Kato K, Murai I, Satoshi A, Matsuno Y, Komuro S, Kaneda N, Iwasaki A, Ishikawa Y, Kuwayama H: Protective role of melatonin and the pineal gland in modulating water immersion restraint stress ulcer in rats. J Clin Gastroenterol 1998;27(suppl 1): S110-S115.
  144. Konturek PCh, Konturek SJ, Brzozowski T, Dembinski A, Zembala M, Mytar B, Hahn EG: Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischemia-induced lesions is mediated by scavenge of oxygen radicals. Scand J Gastroenterol 1997;32:433–438.
    External Resources
  145. Konturek PCh, Konturek SJ, Majka J, Zembala H, Hahn EG: Melatonin affords protection against gastric lesions induced ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effect. Eur J Pharmacol 1997b;122:73–77.
  146. Kazez A, Demirbag M, Ustundag B, Ozercan H, Saglam M: The role of melatonin in prevention of intestinal ischemia-reperfusion injury in rats. J Pediatric Surg 2000;35:1444–1448.
    External Resources
  147. Cabeza J, Motilva V, de la Lastra CA: Mechanisms involved in gastric protection of melatonin on ischemia-reperfusion-induced oxidative damage in rats. Life Sci 2001;68:1405–1415.
    External Resources
  148. Akbulut H, Akbulut KG, Gonul B: Malondialdehyde and glutathione in rat gastric mucosa and effects of exogenous melatonin. Digest Dis Sci 1997;42:1381–1382.
    External Resources
  149. Kato K, Murai I, Asai S, Takahashi Y, MatsunoY, Komuro S, Kurosaka H, Iwasaki A, Ishikawa K, Arakawa Y: Central nervous system action on gastric acid and pepsin secretion in pylorus-ligated rats. Neuro Report 1998;9:2447–2450.
  150. Maestroni GJM: The immunoneuroendocrine role of melatonin. J Pineal Res 1991;4:1–10.
  151. Yanagisawa M, Kachi T: Effects of the pineal hormone on Payer’s patches in the small intestine. Acta Anat Nippon 1994;69:522–527.
  152. Cuzzocrea S, Mazzon E, Serraino I, Lepore V, Terranova ML, Ciccolo A, Caputi AP: Melatonin reduces dintrobenzene sulfonic acid-induced colitis. J Pineal Res 2001;30:1–12.
    External Resources
  153. Weissbluth L, Weissbluth M: Infant colic: The effect of serotonin and melatonin circadian rhythms on the intestinal smooth muscles. Med Hypotheses 1992;39:164–169.
    External Resources
  154. Weissbluth L, Weissbluth M: The photo-biochemical basis of infant colic: Pineal intracellular calcium concentrations controlled by light, melatonin and serotonin. Med Hypotheses 1993;40:158–164.
    External Resources
  155. Anisimov VN, Popovich IG, Zabezhinski A: Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats. Carcinogenesis 1997;18:1549–1553.
    External Resources
  156. Anisimov VN, Kvetnoy IM, Chumakova NK, Kvetnaya TN, Molotkov AO, Pogudina NA, Popovich IG, Popuchiev VV, Zabezhinski MA, Bartsch H, Bartsch C: Melatonin and carcinogenesis. II. Intestinal melatonin-containing cells and serum melatonin levels in rats with 1,2-dimethylhydrazine-induced colon tumors. Exp Toxic Pathol 1999;51:47–52.
    External Resources
  157. Anisimov VN, Popovich IG, Shtylik AV, Zabezhinski MA, Ben-Hu H, Gurevich P, Berman V, Tendler Y, Zusman I: Melatonin and carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats. Exp Toxic Pathol 2000;52:71–76.
    External Resources
  158. Kvetnoy IM, Levin OM: Diurnal melatonin excretion in gastric and rectal cancer. Voprosi onkologii 1987;33:29–32. (in Russian.)
  159. Fraschini F, Demartini G, Esposti, Scaglione F: Melatonin involvement in immunity and cancer. Biol Signals Recept 1998;7:61–72.
    External Resources
  160. Cardinali DP, Brusco LI, Cutrera RA, Castrillon P, Esquifino AI: Melatonin as a time-meaningful signal in circadian organization of immune response. Biol Signals Recept 1999;8:41–48.
    External Resources

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