Intracranial Gliomas Part III - Innovative Treatment Modalities

Editor(s): Chernov, Mikhail F. (Tokyo)
Muragaki, Yoshihiro (Tokyo)
Kesari, Santosh (Santa Monica, CA)
McCutcheon, Ian E. (Houston, TX)
 

Convection-Enhanced Delivery for Management of Malignant Gliomas

Prabhu S.S.

Author affiliations

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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Chernov MF, Muragaki Y, Kesari S, McCutcheon IE (eds): Intracranial Gliomas. Part III - Innovative Treatment Modalities. Prog Neurol Surg. Basel, Karger, 2018, vol 32, pp 152-158
https://doi.org/10.1159/000469687

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: July 10, 2018
Cover Date: 2018

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-06062-1 (Print)
eISBN: 978-3-318-06063-8 (Online)

Abstract

Convection-enhanced delivery (CED) is a novel method of bypassing the blood-brain barrier for administration of therapeutic agents directly into brain with a potential to provide concentrations that cannot be achieved with systemic drug delivery. This technique has grown significantly over the last 20 years with better understanding of the biomechanics of infusion and of the delivery process. Though clinical trials of CED in malignant brain tumors have not yielded the desired results, a number of new biologically active compounds and pharmaceutical preparations, their carriers, modes of delivery, and improved catheter designs are continually being tested, which hold promise for the future.

© 2018 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of  

Published online: July 10, 2018
Cover Date: 2018

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-06062-1 (Print)
eISBN: 978-3-318-06063-8 (Online)

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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