Cardiology

Short Communication

Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype

De Lorenzo A.a, b · Moreira A.S.B.a, b · Muccillo F.B.b · Assad M.b · Tibirica E.V.b, c

Author affiliations

aUniversidade Federal do Rio de Janeiro, bInstituto Nacional de Cardiologia, and cInstituto Oswaldo Cruz, Rio de Janeiro, Brazil

Keywords: Familial hypercholesterolemiaEndothelial progenitor cellsEndothelial functionMicrovascular function

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Cardiology 2017;137:231-236
https://doi.org/10.1159/000470829

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: October 25, 2016
Accepted: February 28, 2017
Published online: May 04, 2017
Issue release date: July 2017

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Objective: To evaluate endothelial progenitor cells (EPCs) and systemic microvascular function in patients with severe hypercholesterolemia, comparing patients with the definite familial hypercholesterolemia (FH) phenotype (DFH) or probable/possible FH phenotype (PFH). There is a large spectrum of atherosclerotic disease between these two clinical phenotypes of FH, and to acquire further knowledge of the pathophysiology of vascular disease in both is desirable. Methods: Subjects with severe hypercholesterolemia, defined as low-density lipoprotein cholesterol (LDL-C) >190 mg/dL, were classified as DFH or PFH and underwent measurement of the number of EPCs by flow cytometry and evaluation of cutaneous microvascular reactivity using a laser speckle contrast-imaging system with iontophoresis of acethylcholine (ACh) or sodium nitroprusside. EPCs were defined as CD45- or CD45low, CD34+CD133+CD309+ cells. Categorical variables were compared using Fisher test and continuous variables with Student t test or Mann-Whitney test, and a value of p < 0.05 was considered statistically significant. Results: Patients with DFH had higher LDL-C than those with PFH. There was no difference in the median number of EPCs between patients with DFH or PFH, but there was a significant reduction of endothelial-dependent, ACh-induced vasodilatation in the former. Conclusion: Patients with DFH have impaired microvascular endothelial-dependent vasodilatation compared to those with PFH, indicating more severe vascular disease in the former.

© 2017 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: October 25, 2016
Accepted: February 28, 2017
Published online: May 04, 2017
Issue release date: July 2017

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

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2017, Vol.137, No. 4

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