Neonatology

 

Glutamate in Cerebral Tissue of Asphyxiated Neonates during the First Week of Life Demonstrated in vivo Using Proton Magnetic Resonance Spectroscopy

Author affiliations

aDepartment of Neonatology, Wilhelmina Children’s Hospital, University Medical Center, bDepartment of Radiology, University Medical Center, Utrecht, The Netherlands

Keywords: NeonateHypoxia-ischemiaProton magnetic resonance spectroscopyGlutamate

Related Articles for ""
Biol Neonate 2001;79:254–257
https://doi.org/10.1159/000047101

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 23, 2001
Issue release date: April 2001

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

We tested the hypothesis that glutamate (Glx) levels as demonstrated by proton magnetic resonance spectroscopy (1H-MRS) are elevated in brain tissue of neonates with severe hypoxic-ischemic encephalopathy (HIE). Studies were performed in 26 neonates (median gestational age 40.5 weeks, range 36.7–42.4 weeks; median birth weight 3,360 g, range 2,180–4,200 g). The median postnatal age at the time of testing was 2.5 days (range 1–7 days). HIE was scored according to Sarnat as grade I (n = 4), grade II (n = 15) or grade III (n = 7). Results for neonates with mild to moderate HIE (group 1) were compared to those with severe HIE (group 2). After magnetic resonance imaging, 1H-MRS was performed in a single volume of interest including the basal ganglia. An echo time of 31 ms was used. After curve-fitting procedures, peak area ratios of different brain metabolites were calculated. The median total Glx/N-acetylaspartate ratio was 1.21 (range 0.64–3.25) in group 1 versus 1.55 (range 1.10–2.75) in group 2 (p = 0.035). The median total Glx/choline ratio was 1.33 (range 0.71–2.52) in group 1 versus 2.14 (range 1.21–3.55) in group 2 (p = 0.019). We concluded that during the first days of life, Glx was elevated in the basal ganglia of neonates with severe HIE.

© 2001 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 23, 2001
Issue release date: April 2001

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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2001, Vol.79, No. 3-4

April 2001

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