Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy

Park H.-K.a · Chung J.-W.b · Hong J.-H.c · Jang M.U.d · Noh H.-D.e · Park J.-M.f · Kang K.f · Lee S.J.g · Ko Y.g · Kim J.G.g · Cha J.-K.h · Kim D.-H.h · Nah H.-W.h · Han M.-K.a · Kim B.J.a · Park T.H.i · Park S.-S.i · Lee K.B.j · Lee J.k · Hong K.-S.l · Cho Y.-J.l · Lee B.-C.m · Yu K.-H.m · Oh M.S.m · Cho K.-H.n · Kim J.-T.n · Kim D.-E.o · Ryu W.-S.o · Choi J.C.p · Kim W.-J.q · Shin D.-I.r · Yeo M.-J.r · Sohn S.-I.c · Lee J.S.s · Lee J.t · Yoon B.-W.u · Bae H.-J.a

Author affiliations

aDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, bDepartment of Neurology, Samsung Medical Center, Seoul, cDepartment of Neurology, Keimyung University Dongsan Medical Center, Daegu, dDepartment of Neurology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, eDepartment of Neurology, Yeungnam University Yeongcheon Hospital, Yeongcheon, fDepartment of Neurology, Eulji General Hospital, Eulji University, Seoul, gDepartment of Neurology, Eulji University Hospital, Eulji University, Daejeon, hDepartment of Neurology, Dong-A University Hospital, Busan, iDepartment of Neurology, Seoul Medical Center, and jDepartment of Neurology, Soonchunhyang University Hospital, Seoul, kDepartment of Neurology, Yeungnam University Hospital, Daegu, lDepartment of Neurology, Ilsan Paik Hospital, Inje University, Goyang, mDepartment of Neurology, Hallym University Sacred Heart Hospital, Anyang, nDepartment of Neurology, Chonnam National University Hospital, Gwangju, oDepartment of Neurology, Dongguk University Ilsan Hospital, Goyang, pDepartment of Neurology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, qDepartment of Neurology, Ulsan University College of Medicine, Ulsan, rDepartment of Neurology, Chungbuk National University Hospital, Cheongju, sClinical Research Center, ASAN Medical Center, tDepartment of Biostatistics, Korea University College of Medicine, and uDepartment of Neurology, Seoul National University Hospital, Seoul, Korea

Related Articles for ""

Cerebrovasc Dis 2017;44:51-58

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 08, 2016
Accepted: September 06, 2016
Published online: April 21, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 ± 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months.

© 2017 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 08, 2016
Accepted: September 06, 2016
Published online: April 21, 2017
Issue release date: Published online first (Issue-in-Progress)

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.