Arrhythmias, Electrophysiology, and Electrocardiography
Determinants of Short-Period Heart Rate Variability in the General PopulationKuch B.a,c · Hense H.W.a · Sinnreich R.d · Kark J.D.d · von Eckardstein A.b · Sapoznikov D.d · Bolte H.-D.c
aInstitute of Epidemiology and Social Medicine and bInstitute of Clinical Chemistry and Laboratory Medicine, University of Münster, and cDepartment of Medicine I, Central Hospital Augsburg, Academic Training Clinic University Munich, Germany; dDepartment of Social Medicine and Department of Cardiology, Hadassah Medical Organization and Hebrew University-Hadassah School of Public Health, Jerusalem, Israel
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Decreased heart rate variability (HRV) is associated with a worse prognosis in a variety of diseases and disorders. We evaluated the determinants of short-period HRV in a random sample of 149 middle-aged men and 137 women from the general population. Spectral analysis was used to compute low-frequency (LF), high-frequency (HF) and total-frequency power. HRV showed a strong inverse association with age and heart rate in both sexes with a more pronounced effect of heart rate on HRV in women. Age and heart rate-adjusted LF was significantly higher in men and HF higher in women. Significant negative correlations of BMI, triglycerides, insulin and positive correlations of HDL cholesterol with LF and total power occurred only in men. In multivariate analyses, heart rate and age persisted as prominent independent predictors of HRV. In addition, BMI was strongly negatively associated with LF in men but not in women. We conclude that the more pronounced vagal influence in cardiac regulation in middle-aged women and the gender-different influence of heart rate and metabolic factors on HRV may help to explain the lower susceptibility of women for cardiac arrhythmias.
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